Plasmodium Kinases as Potential Drug Targets for Malaria: Challenges and Opportunities
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DOI: 10.1021/acsinfecdis.0c00724
Abstract: Protein and phosphoinositide kinases have been successfully exploited as drug targets in various disease areas, principally in oncology. In malaria, several protein kinases are under investigation as potential drug targets, and an inhibitor of Plasmodium… read more here.
Keywords: drug targets; plasmodium kinases; kinase; drug ... See more keywords
The anticancer human mTOR inhibitor sapanisertib potently inhibits multiple Plasmodium kinases and life cycle stages
Sign Up to like & getrecommendations! Published in 2022 at "Science Translational Medicine"
DOI: 10.1126/scitranslmed.abo7219
Abstract: Compounds acting on multiple targets are critical to combating antimalarial drug resistance. Here, we report that the human “mammalian target of rapamycin” (mTOR) inhibitor sapanisertib has potent prophylactic liver stage activity, in vitro and in… read more here.
Keywords: sapanisertib; plasmodium kinases; plasmodium; activity ... See more keywords
Divergent Plasmodium kinases drive MTOC, kinetochore and axoneme organisation in male gametogenesis
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DOI: 10.26508/lsa.202403056
Abstract: This study reveals how Plasmodium kinases regulate MTOC, axoneme, and kinetochore organisation in male gametogenesis, providing key insights into potential targets for malaria transmission control. Sexual development and male gamete formation of the malaria parasite… read more here.
Keywords: kinetochore; plasmodium kinases; male gametogenesis; male ... See more keywords