Epidemiology of the zoonotic malaria Plasmodium knowlesi in changing landscapes.
Sign Up to like & getrecommendations! Published in 2021 at "Advances in parasitology"
DOI: 10.1016/bs.apar.2021.08.006
Abstract: Within the past two decades, incidence of human cases of the zoonotic malaria Plasmodium knowlesi has increased markedly. P. knowlesi is now the most common cause of human malaria in Malaysia and threatens to undermine… read more here.
Keywords: malaria plasmodium; plasmodium knowlesi; epidemiology; zoonotic malaria ... See more keywords
Infection of mosquitoes from in vitro cultivated Plasmodium knowlesi H strain.
Sign Up to like & getrecommendations! Published in 2018 at "International journal for parasitology"
DOI: 10.1016/j.ijpara.2018.02.004
Abstract: In vitro studies of sexual blood stages of the most fatal malaria species, Plasmodium falciparum, have revealed key processes by which gametocytes develop and transmit infection from humans to anopheline mosquitoes. However, most malaria cases… read more here.
Keywords: knowlesi; mosquitoes vitro; plasmodium knowlesi; vitro cultivated ... See more keywords
The Plasmodium knowlesi MAHRP2 ortholog localizes to structures connecting Sinton Mulligan's clefts in the infected erythrocyte.
Sign Up to like & getrecommendations! Published in 2018 at "Parasitology international"
DOI: 10.1016/j.parint.2018.04.005
Abstract: During development within the host erythrocyte malaria parasites generate nascent membranous structures which serve as a pathway for parasite protein transport to modify the host cell. The molecular basis of such membranous structures is not… read more here.
Keywords: mulligan clefts; knowlesi; sinton mulligan; plasmodium knowlesi ... See more keywords
Characterization of Plasmodium knowlesi dihydrofolate reductase-thymidylate synthase and sensitivity to antifolates.
Sign Up to like & getrecommendations! Published in 2018 at "Parasitology international"
DOI: 10.1016/j.parint.2018.08.004
Abstract: Malaria caused by an infection of Plasmodium knowlesi can result in high parasitemia and deaths. Therefore, effective and prompt treatment is necessary to reduce morbidity and mortality. The study aims to characterize P. knowlesi dihydrofolate… read more here.
Keywords: sensitivity antifolates; reductase thymidylate; dihydrofolate reductase; knowlesi dihydrofolate ... See more keywords
The Treatment of Plasmodium knowlesi Malaria.
Sign Up to like & getrecommendations! Published in 2017 at "Trends in parasitology"
DOI: 10.1016/j.pt.2016.09.002
Abstract: Plasmodium knowlesi occurs across Southeast Asia and is the most common cause of malaria in Malaysia. High parasitaemias can develop rapidly, and the risk of severe disease in adults is at least as high as… read more here.
Keywords: treatment; knowlesi malaria; knowlesi; plasmodium knowlesi ... See more keywords
Cellular dissection of malaria parasite invasion of human erythrocytes using viable Plasmodium knowlesi merozoites
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-28457-z
Abstract: Plasmodium knowlesi, a zoonotic parasite causing severe-to-lethal malaria disease in humans, has only recently been adapted to continuous culture with human red blood cells (RBCs). In comparison with the most virulent human malaria, Plasmodium falciparum,… read more here.
Keywords: invasion; plasmodium knowlesi; dissection; plasmodium ... See more keywords
New vectors that are early feeders for Plasmodium knowlesi and other simian malaria parasites in Sarawak, Malaysian Borneo
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DOI: 10.1038/s41598-021-86107-3
Abstract: Plasmodium knowlesi is the main cause of malaria in Sarawak, where studies on vectors of P. knowlesi have been conducted in only two districts. Anopheles balabacensis and An. donaldi were incriminated as vectors in Lawas… read more here.
Keywords: malaria; new vectors; vectors early; early feeders ... See more keywords
Developing a Predictive Model for Plasmodium knowlesi-Susceptible Areas in Malaysia Using Geospatial Data and Artificial Neural Networks.
Sign Up to like & getrecommendations! Published in 2021 at "Asia-Pacific journal of public health"
DOI: 10.1177/10105395211048620
Abstract: Plasmodium knowlesi is an emerging species for malaria in Malaysia, particularly in East Malaysia. This infection contributes to almost half of all malaria cases and deaths in Malaysia and poses a challenge in eradicating malaria.… read more here.
Keywords: knowlesi; malaria cases; predictive model; plasmodium knowlesi ... See more keywords
Reduced circulating dendritic cells in acute Plasmodium knowlesi and Plasmodium falciparum malaria despite elevated plasma Flt3 ligand levels
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DOI: 10.1186/s12936-021-03642-0
Abstract: Background Plasmodium falciparum malaria increases plasma levels of the cytokine Fms-like tyrosine kinase 3 ligand (Flt3L), a haematopoietic factor associated with dendritic cell (DC) expansion. It is unknown if the zoonotic parasite Plasmodium knowlesi impacts… read more here.
Keywords: knowlesi; malaria; plasmodium knowlesi; plasmodium falciparum ... See more keywords
Identification and validation of a novel panel of Plasmodium knowlesi biomarkers of serological exposure
Sign Up to like & getrecommendations! Published in 2018 at "PLoS Neglected Tropical Diseases"
DOI: 10.1371/journal.pntd.0006457
Abstract: Background Plasmodium knowlesi is the most common cause of malaria in Malaysian Borneo, with reporting limited to clinical cases presenting to health facilities and scarce data on the true extent of transmission. Serological estimations of… read more here.
Keywords: knowlesi; validation; exposure; plasmodium knowlesi ... See more keywords
Anopheles sundaicus Mosquitoes as Vector for Plasmodium knowlesi, Andaman and Nicobar Islands, India
Sign Up to like & getrecommendations! Published in 2019 at "Emerging Infectious Diseases"
DOI: 10.3201/eid2504.181668
Abstract: Using PCR and sequencing, we found Plasmodium knowlesi in the malaria vector Anopheles sundaicus mosquito collected from Katchal Island in the Andaman and Nicobar Islands, India. We cannot rule out natural transmission of this parasite… read more here.
Keywords: andaman nicobar; islands india; nicobar islands; plasmodium knowlesi ... See more keywords