Cryo-Em Structure of the Plasmodium Proteasome in the Search of New Antimalarials
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2016.11.1785
Abstract: The Plasmodium falciparum proteasome has been suggested as possible target for new generation antimalarials. However, the proteasome is essential in all eukaryotes and a proteasome inhibitor with potential to be developed as antimalarial must specifically… read more here.
Keywords: cryo structure; plasmodium proteasome; structure; plasmodium ... See more keywords
Structure-Activity Relationship Studies of Antimalarial Plasmodium Proteasome Inhibitors─Part II.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c01651
Abstract: With increasing reports of resistance to artemisinins and artemisinin-combination therapies, targeting the Plasmodium proteasome is a promising strategy for antimalarial development. We recently reported a highly selective Plasmodium falciparum proteasome inhibitor with anti-malarial activity in… read more here.
Keywords: structure activity; plasmodium; proteasome; plasmodium proteasome ... See more keywords