A novel Plasmodium yoelii pseudokinase, PypPK1, is involved in erythrocyte invasion and exflagellation center formation.
Sign Up to like & getrecommendations! Published in 2020 at "Parasitology international"
DOI: 10.1016/j.parint.2020.102056
Abstract: Malaria parasites proliferate by repeated invasion of and multiplication within erythrocytes in the vertebrate host. Sexually committed intraerythrocytic parasites undergo sexual stage differentiation to become gametocytes. After ingestion by the mosquito, male and female gametocytes… read more here.
Keywords: invasion; invasion exflagellation; plasmodium yoelii; erythrocyte invasion ... See more keywords
cAMP-dependent protein kinase regulates secretion of apical membrane antigen 1 (AMA1) in Plasmodium yoelii.
Sign Up to like & getrecommendations! Published in 2021 at "Parasitology international"
DOI: 10.1016/j.parint.2021.102435
Abstract: Malaria remains a heavy global burden on human health, and it is important to understand the molecular and cellular biology of the parasite to find targets for drug and vaccine development. The mouse malaria model… read more here.
Keywords: camp dependent; dependent protein; yoelii; plasmodium yoelii ... See more keywords
Dissecting Plasmodium yoelii Pathobiology: Proteomic Approaches for Decoding Novel Translational and Post-Translational Modifications
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DOI: 10.1021/acsomega.1c03892
Abstract: Malaria is a vector-borne disease. It is caused by Plasmodium parasites. Plasmodium yoelii is a rodent model parasite, primarily used for studying parasite development in liver cells and vectors. To better understand parasite biology, we… read more here.
Keywords: plasmodium yoelii; post translational; analysis; translational modifications ... See more keywords
A Plasmodium yoelii HECT-like E3 ubiquitin ligase regulates parasite growth and virulence
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DOI: 10.1038/s41467-017-00267-3
Abstract: Infection of mice with strains of Plasmodium yoelii parasites can result in different pathology, but molecular mechanisms to explain this variation are unclear. Here we show that a P. yoelii gene encoding a HECT-like E3… read more here.
Keywords: virulence; ubiquitin ligase; parasite growth; plasmodium yoelii ... See more keywords
Systematic CRISPR-Cas9-Mediated Modifications of Plasmodium yoelii ApiAP2 Genes Reveal Functional Insights into Parasite Development
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DOI: 10.1128/mbio.01986-17
Abstract: ABSTRACT Malaria parasites have a complex life cycle with multiple developmental stages in mosquito and vertebrate hosts, and different developmental stages express unique sets of genes. Unexpectedly, many transcription factors (TFs) commonly found in eukaryotic… read more here.
Keywords: parasite development; apiap2 genes; plasmodium yoelii; yoelii apiap2 ... See more keywords
Definition of constitutive and stage-enriched promoters in the rodent malaria parasite, Plasmodium yoelii
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DOI: 10.1186/s12936-020-03498-w
Abstract: Background Well-defined promoters are essential elements for genetic studies in all organisms, and enable controlled expression of endogenous genes, transgene expression, and gene editing. Despite this, there is a paucity of defined promoters for the… read more here.
Keywords: stage enriched; gene editing; plasmodium yoelii; gene ... See more keywords
Memory CD73+IgM+ B cells protect against Plasmodium yoelii infection and express Granzyme B
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DOI: 10.1371/journal.pone.0238493
Abstract: To better understand anti-malaria protective immune responses, we examined the cellular mechanisms that govern protective immunity in a murine Plasmodium yoelii 17X NL (PyNL) re-infection model. Initially, we confirmed that immune B cells generated during… read more here.
Keywords: cd73 cells; infection; pynl infection; cd73 ... See more keywords
Properties and Roles of γδT Cells in Plasmodium yoelii nigeriensis NSM Infected C57BL/6 Mice
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cellular and Infection Microbiology"
DOI: 10.3389/fcimb.2021.788546
Abstract: Background Many kinds of immune cells are involved in malaria infection. γδT cells represent a special type of immune cell between natural and adaptive immune cells that play critical roles in anti-parasite infection. Methods In… read more here.
Keywords: plasmodium yoelii; yoelii nigeriensis; infection; mice ... See more keywords