Emergence of a High-Plasticity Cell State during Lung Cancer Evolution.
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DOI: 10.1016/j.ccell.2020.06.012
Abstract: Tumor evolution from a single cell into a malignant, heterogeneous tissue remains poorly understood. Here, we profile single-cell transcriptomes of genetically engineered mouse lung tumors at seven stages, from pre-neoplastic hyperplasia to adenocarcinoma. The diversity… read more here.
Keywords: plasticity cell; evolution; cell state; high plasticity ... See more keywords