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Published in 2019 at "Molecular cell"
DOI: 10.1016/j.molcel.2019.07.013
Abstract: Inducing protein degradation via small molecules is a transformative therapeutic paradigm. Although structural requirements of target degradation are emerging, mechanisms determining the cellular response to small-molecule degraders remain poorly understood. To systematically delineate effectors required for…
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Keywords:
degradation;
cullin ring;
sensitivity;
plasticity cullin ... See more keywords