Substrate Plasticity of a Fungal Peptide α-N-Methyltransferase
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DOI: 10.1021/acschembio.0c00237
Abstract: The methylation of amide nitrogen atoms can improve the stability, oral availability, and cell permeability of peptide therapeutics. Chemical N-methylation of peptides is challenging. Omphalotin A is a ribosomally synthesized, macrocylic dodecapeptide with nine backbone… read more here.
Keywords: peptide methyltransferase; peptide; fungal peptide; methyltransferase ... See more keywords