Astrocytic A2A receptors silencing negatively impacts hippocampal synaptic plasticity and memory of adult mice.
Sign Up to like & getrecommendations! Published in 2023 at "Glia"
DOI: 10.1002/glia.24384
Abstract: Astrocytes are wired to bidirectionally communicate with neurons namely with synapses, thus shaping synaptic plasticity, which in the hippocampus is considered to underlie learning and memory. Adenosine A2A receptors (A2A R) are a potential candidate… read more here.
Keywords: synaptic plasticity; plasticity memory; astrocytic a2a; plasticity ... See more keywords
Reinstating plasticity and memory in a tauopathy mouse model with an acetyltransferase activator
Sign Up to like & getrecommendations! Published in 2018 at "EMBO Molecular Medicine"
DOI: 10.15252/emmm.201708587
Abstract: Chromatin acetylation, a critical regulator of synaptic plasticity and memory processes, is thought to be altered in neurodegenerative diseases. Here, we demonstrate that spatial memory and plasticity (LTD, dendritic spine formation) deficits can be restored… read more here.
Keywords: activator; csp ttk21; plasticity memory; mouse model ... See more keywords
Specific depletion of the motor protein KIF5B leads to deficits in dendritic transport, synaptic plasticity and memory
Sign Up to like & getrecommendations! Published in 2020 at "eLife"
DOI: 10.7554/elife.53456
Abstract: The kinesin I family of motor proteins are crucial for axonal transport, but their roles in dendritic transport and postsynaptic function are not well-defined. Gene duplication and subsequent diversification give rise to three homologous kinesin… read more here.
Keywords: transport; plasticity memory; deficits dendritic; motor ... See more keywords