Ketamine and its metabolite (2R,6R)-hydroxynorketamine induce lasting alterations in glutamatergic synaptic plasticity in the mesolimbic circuit
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DOI: 10.1038/mp.2017.239
Abstract: Low doses of ketamine trigger rapid and lasting antidepressant effects after one injection in treatment-resistant patients with major depressive disorder. Modulation of AMPA receptors (AMPARs) in the hippocampus and prefrontal cortex is suggested to mediate… read more here.
Keywords: plasticity mesolimbic; hydroxynorketamine; ketamine; synaptic plasticity ... See more keywords