Impact of Lineage Plasticity to and from a Neuroendocrine Phenotype on Progression and Response in Prostate and Lung Cancers.
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DOI: 10.1016/j.molcel.2020.10.033
Abstract: Intratumoral heterogeneity can occur via phenotype transitions, often after chronic exposure to targeted anticancer agents. This process, termed lineage plasticity, is associated with acquired independence to an initial oncogenic driver, resulting in treatment failure. In… read more here.
Keywords: prostate; impact lineage; plasticity neuroendocrine; lineage plasticity ... See more keywords