Evaluation of the Association of Platelet Count, Mean Platelet Volume, and Platelet Transfusion With Intraventricular Hemorrhage and Death Among Preterm Infants
Sign Up to like & getrecommendations! Published in 2022 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2022.37588
Abstract: Key Points Question What are the associations of platelet transfusion, platelet count (PC), and mean platelet volume (MPV) with intraventricular hemorrhage (IVH) and mortality in preterm infants? Findings In this cohort study of 1221 preterm… read more here.
Keywords: count mean; platelet transfusion; preterm infants; platelet ... See more keywords
Platelet Transfusion and Death or Neurodevelopmental Impairment in Children Born Extremely Preterm
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DOI: 10.1001/jamanetworkopen.2023.52394
Abstract: Key Points Question Are platelet transfusions associated with death or neurodevelopmental impairment in children born extremely preterm? Findings In this cohort study of 819 infants born extremely preterm enrolled in a clinical trial of erythropoietin… read more here.
Keywords: neurodevelopmental impairment; born extremely; platelet; extremely preterm ... See more keywords
Fluorinated Hydrophobic Silk as Platelet Compatible Coatings for Platelet Conservation and Storage Applications
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DOI: 10.1002/adfm.202508074
Abstract: Platelet transfusions are critical medical procedures for patients experiencing life‐threatening conditions. However, there are challenges owing to the high propensity of platelet activation when exposed to foreign surfaces, leading to aggregation and depletion of platelet… read more here.
Keywords: silk platelet; silk; hydrophobic silk; platelet ... See more keywords
Annexin V‐Modified Platelet‐Biomimetic Nanomedicine for Targeted Therapy of Acute Ischemic Stroke
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DOI: 10.1002/adhm.202200416
Abstract: Thromboembolic stroke is typically characterized by the activation of platelets, resulting in thrombus in the cerebral vascular system, leading to high morbidity and mortality globally. Intravenous thrombolysis by tissue plasminogen activator (tPA) administration within 4.5… read more here.
Keywords: platelet biomimetic; acute ischemic; platelet; ischemic stroke ... See more keywords
Platelet Adhesion and Activation in an ECMO Thrombosis‐on‐a‐Chip Model
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DOI: 10.1002/advs.202401524
Abstract: Use of extracorporeal membrane oxygenation (ECMO) for cardiorespiratory failure remains complicated by blood clot formation (thrombosis), triggered by biomaterial surfaces and flow conditions. Thrombosis may result in ECMO circuit changes, cause red blood cell hemolysis,… read more here.
Keywords: thrombosis chip; ecmo thrombosis; platelet; chip model ... See more keywords
Bioprinting Soft 3D Models of Hematopoiesis using Natural Silk Fibroin‐Based Bioink Efficiently Supports Platelet Differentiation (Adv. Sci. 18/2024)
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DOI: 10.1002/advs.202470103
Abstract: Developing a Silk‐Based Bioink Article number 2308276 by Alessandra Balduini focuses on developing a silk‐based bioink specifically tailored to replicate the softness of the hematopoietic niche within the bone marrow microenvironment. The aim is to… read more here.
Keywords: differentiation; based bioink; silk; platelet ... See more keywords
BMI is an important determinant of VWF and FVIII levels and bleeding phenotype in patients with von Willebrand disease
Sign Up to like & getrecommendations! Published in 2019 at "American Journal of Hematology"
DOI: 10.1002/ajh.25499
Abstract: observed during eltrombopag treatment or at the follow-up visits routinely performed 30 days after surgery. As eltrombopag has been associated with occurrence of cataracts in patients with immune thrombocytopenia, and MYH9-RD is a syndromic disorder… read more here.
Keywords: important determinant; determinant vwf; eltrombopag; bmi important ... See more keywords
Platelets from Calreticulin mutated essential thrombocythemia patients are less reactive than JAK2 V617F mutated platelets
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DOI: 10.1002/ajh.25713
Abstract: Both JAK2V617F and calreticulin (CALR) mutated essential thrombocythemia (ET) patients have different clinical characteristics, with lower thrombosis risk in patients with CALR mutations. To elucidate the mechanism for this lower risk we studied platelet function… read more here.
Keywords: calr mutated; mutated platelets; platelet; mutated essential ... See more keywords
Familial thrombocytopenia flare‐up following the first dose of mRNA‐1273 Covid‐19 vaccine
Sign Up to like & getrecommendations! Published in 2021 at "American Journal of Hematology"
DOI: 10.1002/ajh.26128
Abstract: To the Editor: A 36-year-old female with a past medical history of thrombocytopenia, previously classified as immune thrombocytopenic purpura (ITP), presented to the hospital with diffuse petechiae, easy bruising, bleeding gums and a mild headache.… read more here.
Keywords: thrombocytopenia; covid vaccine; mrna 1273; vaccine ... See more keywords
Iron and platelets: A subtle, under‐recognized relationship
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DOI: 10.1002/ajh.26189
Abstract: The role of iron in the formation and functioning of erythrocytes, and to a lesser degree of white blood cells, is well established, but the relationship between iron and platelets is less documented. Physiologically, iron… read more here.
Keywords: iron platelets; relationship iron; platelets subtle; iron ... See more keywords
Safety of intravenous arginine therapy in children with sickle cell disease hospitalized for vaso‐occlusive pain: A randomized placebo‐controlled trial in progress
Sign Up to like & getrecommendations! Published in 2021 at "American Journal of Hematology"
DOI: 10.1002/ajh.26396
Abstract: 1. Semple JW, Italiano JE, Freedman J. Platelets and the immune continuum. Nat Rev Immunol. 2011;11(4):264-274. 2. Sol N, Wurdinger T. Platelet RNA signatures for the detection of cancer. Cancer Metastasis Rev. 2017;36(2):263-272. 3. Franco… read more here.
Keywords: cancer; platelet; cell; tumor educated ... See more keywords