Flow cytometric kinetic assay of calcium mobilization in whole blood platelets of bottlenose dolphins (Tursiops truncatus)
Sign Up to like & getrecommendations! Published in 2022 at "Cytometry Part A"
DOI: 10.1002/cyto.a.24693
Abstract: Marine mammals may suffer alterations in platelet function and hemostasia due to multiple pathologies, environmental conditions (including stress) or exposure to different contaminants that induce platelet activation. Detecting early alterations in platelet function in these… read more here.
Keywords: platelet activation; kinetic assay; whole blood; bottlenose dolphins ... See more keywords
Evaluation of platelet activation marker expression and its correlation with tumorigenesis and tumor progression in patients with gastric cancer
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Surgical Oncology"
DOI: 10.1002/jso.26908
Abstract: Gastric cancer (GC) remains responsible for over one million new cases in 2020. Activated platelets express the CD40 ligand (CD40L) and CD62P in the cytoplasmic membrane, and interaction with the vascular endothelium can induce the… read more here.
Keywords: platelet activation; gastric cancer; evaluation platelet; activation marker ... See more keywords
On-Chip Platelet Activation Assessment: Microfluidic Emulation of Shear Stress Profiles Induced by Mechanical Circulatory Support Devices.
Sign Up to like & getrecommendations! Published in 2022 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-1693-2_12
Abstract: Mechanical circulatory support devices (MCSDs), although proved to be a pillar in the clinical setting of advanced heart failure, are afflicted by thromboembolic complications. Shear-mediated platelet activation has been recognized to drive thromboembolic events in… read more here.
Keywords: platelet activation; platelet; shear stress; mechanical circulatory ... See more keywords
Platelet Activation Markers in Children with Pulmonary Arterial Hypertension Associated with Congenital Heart Disease
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DOI: 10.1007/s00246-022-02847-7
Abstract: The study aimed to evaluate mean platelet volume (MPV), platelet distribution width (PDW), and platecrit in children with pulmonary arterial hypertension associated with congenital heart disease (PAH-CHD), to assess the predictive value of these platelet… read more here.
Keywords: group; pdw platecrit; platelet; activation markers ... See more keywords
Numerical Study of Blood Clots Influence on the Flow Pattern and Platelet Activation on a Stented Bifurcation Model
Sign Up to like & getrecommendations! Published in 2017 at "Annals of Biomedical Engineering"
DOI: 10.1007/s10439-016-1782-4
Abstract: Stent implantation is a common procedure followed in arteries affected by atherosclerosis. This procedure can lead to other stenting-related problems. One of these is the deposition and accumulation of blood clots over stent struts. This… read more here.
Keywords: platelet activation; bifurcation; flow pattern;
Ticagrelor Inhibits Toll-Like and Protease-Activated Receptor Mediated Platelet Activation in Acute Coronary Syndromes
Sign Up to like & getrecommendations! Published in 2020 at "Cardiovascular Drugs and Therapy"
DOI: 10.1007/s10557-019-06932-7
Abstract: Purpose Since ticagrelor inhibits the cellular uptake of adenosine, thereby increasing extracellular adenosine concentration and biological activity, we hypothesized that ticagrelor has adenosine-dependent antiplatelet properties. In the current study, we compared the effects of ticagrelor… read more here.
Keywords: platelet activation; platelet; platelet surface; ticagrelor inhibits ... See more keywords
Flow cytometric analysis reveals the high levels of platelet activation parameters in circulation of multiple sclerosis patients
Sign Up to like & getrecommendations! Published in 2017 at "Molecular and Cellular Biochemistry"
DOI: 10.1007/s11010-017-2955-7
Abstract: The epidemiological studies confirm an increased risk of cardiovascular disease in multiple sclerosis, especially prothrombotic events directly associated with abnormal platelet activity. The aim of our study was to investigate the level of blood platelet… read more here.
Keywords: platelet activation; multiple sclerosis; activation; level ... See more keywords
The effect of hydroxychloroquine on platelet activation in model experiments
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Thrombosis and Thrombolysis"
DOI: 10.1007/s11239-020-02325-y
Abstract: Hydroxychloroquine (HCQ) is an antimalarial agent with pleiotropic effects and now represents a cornerstone in the management of patients with autoimmune conditions. While clinical series suggest anti-thrombotic properties, the way in which HCQ exerts this… read more here.
Keywords: effect; expression cd40l; hcq; platelet activation ... See more keywords
Increased platelet activation in sleep apnea subjects with intermittent hypoxemia
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DOI: 10.1007/s11325-020-02021-4
Abstract: Purpose Obstructive sleep apnea (OSA) is independently associated with increased risk for stroke and other cardiovascular diseases. Since activated platelets play an important role in cardiovascular disease, the objective of this study was to determine… read more here.
Keywords: hypoxemia; platelet activation; sleep apnea; platelet ... See more keywords
Platelet activation and placenta-mediated adverse pregnancy outcomes: an ancillary study to the EAGeR trial.
Sign Up to like & getrecommendations! Published in 2020 at "American journal of obstetrics and gynecology"
DOI: 10.1016/j.ajog.2020.05.026
Abstract: BACKGROUND Platelet activation may play a role in the pathophysiology of placenta-mediated obstetric complications, as evidenced by the efficacy of aspirin for preventing preeclampsia, but published data regarding the relationship between biomarkers for platelet activation… read more here.
Keywords: pregnancy; aspirin; platelet activation; platelet factor ... See more keywords
STIM1 R304W causes muscle degeneration and impaired platelet activation in mice.
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DOI: 10.1016/j.ceca.2018.10.001
Abstract: STIM1 and ORAI1 regulate store-operated Ca2+ entry (SOCE) in most cell types, and mutations in these proteins have deleterious and diverse effects. We established a mouse line expressing the STIM1 R304 W gain-of-function mutation causing Stormorken… read more here.
Keywords: stim1; platelet activation; muscle degeneration; impaired platelet ... See more keywords