A Commercial Non-Binding Surface Effectively Reduces Fibrinogen Adsorption but Does Not Prevent Platelet Adhesion to Fibrinogen.
Sign Up to like & getrecommendations! Published in 2023 at "Macromolecular bioscience"
DOI: 10.1002/mabi.202300052
Abstract: A commercial non-binding surface effectively prevents protein adsorption, however, the platelet phenotype on this surface has yet to be defined. This study evaluates platelet adhesion and adsorption of several plasma/extra-cellular matrix (ECM) proteins to the… read more here.
Keywords: binding surface; adsorption; fibrinogen; platelet adhesion ... See more keywords
In Vitro Measurements of Shear-Mediated Platelet Adhesion Kinematics as Analyzed through Machine Learning.
Sign Up to like & getrecommendations! Published in 2021 at "Annals of biomedical engineering"
DOI: 10.1007/s10439-021-02790-3
Abstract: Platelet adhesion to blood vessel walls in shear flow is essential to initiating the blood coagulation cascade and prompting clot formation in vascular disease processes and prosthetic cardiovascular devices. Validation of predictive adhesion kinematics models… read more here.
Keywords: platelet adhesion; shear mediated; kinematics; adhesion kinematics ... See more keywords
The Effects of Micro-vessel Curvature Induced Elongational Flows on Platelet Adhesion.
Sign Up to like & getrecommendations! Published in 2021 at "Annals of biomedical engineering"
DOI: 10.1007/s10439-021-02870-4
Abstract: The emerging profile of blood flow and the cross-sectional distribution of blood cells have far reaching biological consequences in various diseases and vital internal processes, such as platelet adhesion. The effects of several essential blood… read more here.
Keywords: platelet adhesion; adhesion; blood; shear rate ... See more keywords
Prediction of Thrombus Growth: Effect of Stenosis and Reynolds Number
Sign Up to like & getrecommendations! Published in 2017 at "Cardiovascular Engineering and Technology"
DOI: 10.1007/s13239-017-0304-3
Abstract: Shear stresses play a major role in platelet-substrate interactions and thrombus formation and growth in blood flow, where under both pathological and physiological conditions platelet adhesion and accumulation occur. In this study, a shear-dependent continuum… read more here.
Keywords: platelet adhesion; reynolds number; adhesion; stenosis ... See more keywords
In Vitro Measurement and Modeling of Platelet Adhesion on VWF-Coated Surfaces in Channel Flow.
Sign Up to like & getrecommendations! Published in 2019 at "Biophysical journal"
DOI: 10.1016/j.bpj.2019.01.040
Abstract: The process of platelet adhesion is initiated by glycoprotein (GP)Ib and GPIIbIIIa receptors on the platelet surface binding with von Willebrand factor on the vascular walls. This initial adhesion and detachment of a single platelet… read more here.
Keywords: platelet adhesion; vitro measurement; adhesion; level ... See more keywords
Von Willebrand Factor-GP1bα Interactions in Venoarterial Extracorporeal Membrane Oxygenation Patients.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of cardiothoracic and vascular anesthesia"
DOI: 10.1053/j.jvca.2018.11.031
Abstract: OBJECTIVE Evaluate extracorporeal membrane oxygenation (ECMO) patients' platelet adhesion and aggregation under shear stress and determine whether addition of von Willebrand factor (VWF) concentrate improves platelet function. Also, explore whether reduced platelet adhesion and aggregation… read more here.
Keywords: platelet adhesion; ecmo patients; auc; day ... See more keywords
Important Regulatory Roles of Erythrocytes on Platelet Adhesion to the von Willebrand Factor on the Wall Under Blood Flow Conditions.
Sign Up to like & getrecommendations! Published in 2021 at "Thrombosis and haemostasis"
DOI: 10.1055/a-1677-9499
Abstract: The roles of erythrocytes on platelet adhesion to von Willebrand factor (VWF) on the vessel wall through their membrane glycoprotein (GP)Ibα under blood flow condition is still to be elucidated. Blood specimens containing fluorescently labeled… read more here.
Keywords: platelet adhesion; erythrocytes platelet; roles erythrocytes; adhesion ... See more keywords
Contributing role of mitochondrial energy metabolism on platelet adhesion, activation and thrombus formation under blood flow conditions
Sign Up to like & getrecommendations! Published in 2022 at "Platelets"
DOI: 10.1080/09537104.2022.2046722
Abstract: Abstract Platelets have an active energy metabolism mediated by mitochondria. However, the role of mitochondria in platelet adhesion, activation, and thrombus formation under blood flow conditions remains to be elucidated. Blood specimens were obtained from… read more here.
Keywords: adhesion; platelet adhesion; adhesion activation; presence ... See more keywords
P721Shear stress induced unfolding of von willebrand factor may be involved in the premature development of myocardial infarction
Sign Up to like & getrecommendations! Published in 2019 at "European Heart Journal"
DOI: 10.1093/eurheartj/ehz747.0326
Abstract: Normally, von Willebrand factor (vWF) becomes highly reactive with platelets upon unfolding into a fibrillar conformation at critical shear rate (more than 5000 s–1), that may occur in stenotic arteries. At shear rates below critical… read more here.
Keywords: platelet adhesion; myocardial infarction; shear rates; infarction ... See more keywords
The physical spacing between the von Willebrand factor D'D3 and A1 domains regulates platelet adhesion in vitro and in vivo
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Thrombosis and Haemostasis"
DOI: 10.1111/jth.13927
Abstract: Essentials The role of von Willebrand factor (VWF) domains in regulating platelet adhesion was studied in vivo. Multimeric VWF with spacers at the N‐ and C‐terminus of VWF‐A1 were systematically tested. N‐terminal modified VWF avidly… read more here.
Keywords: platelet adhesion; von willebrand; willebrand factor;
Glycosylation sterically inhibits platelet adhesion to von Willebrand factor without altering intrinsic conformational dynamics
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Thrombosis and Haemostasis"
DOI: 10.1111/jth.14628
Abstract: A molecular basis for von Willebrand factor (VWF) self‐inhibition has been proposed by which the N‐terminal and C‐terminal flanking sequences of the globular A1 domain disulfide loop bind to and suppress the conformational dynamics of… read more here.
Keywords: platelet adhesion; conformational dynamics; von willebrand; willebrand factor ... See more keywords