Phosphatidylserine-mediated platelet clearance by endothelium decreases platelet aggregates and procoagulant activity in sepsis
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DOI: 10.1038/s41598-017-04773-8
Abstract: The mechanisms that eliminate activated platelets in inflammation-induced disseminated intravascular coagulation (DIC) in micro-capillary circulation are poorly understood. This study explored an alternate pathway for platelet disposal mediated by endothelial cells (ECs) through phosphatidylserine (PS)… read more here.
Keywords: sepsis; platelet clearance; procoagulant activity; clearance ... See more keywords
Desialylation of O-glycans on glycoprotein Ibα drives receptor signaling and platelet clearance
Sign Up to like & getrecommendations! Published in 2020 at "Haematologica"
DOI: 10.3324/haematol.2019.240440
Abstract: During infection neuraminidase desialylates platelets and induces their rapid clearance from circulation. The underlying molecular basis, particularly the role of platelet glycoprotein (GP)Ibα therein, is not clear. Utilizing genetically altered mice, we report that the… read more here.
Keywords: platelet clearance; desialylation glycans; gpib; clearance ... See more keywords