Discovery and Development of First-in-Class ACKR3/CXCR7 Superagonists for Platelet Degranulation Modulation.
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DOI: 10.1021/acs.jmedchem.2c01198
Abstract: The atypical chemokine receptor 3 (ACKR3), formerly known as CXC-chemokine receptor 7 (CXCR7), has been postulated to regulate platelet function and thrombus formation. Herein, we report the discovery and development of first-in-class ACKR3 agonists, which… read more here.
Keywords: discovery development; platelet degranulation; cxcr7; first class ... See more keywords
Protein Network Analysis Identifies Changes in the Level of Proteins Involved in Platelet Degranulation, Proteolysis and Cholesterol Metabolism Pathways in AECOPD Patients
Sign Up to like & getrecommendations! Published in 2020 at "COPD: Journal of Chronic Obstructive Pulmonary Disease"
DOI: 10.1080/15412555.2019.1711035
Abstract: Abstract Chronic obstructive pulmonary disease (COPD) is characterised by a progressive pulmonary and systemic inflammation. Acute exacerbations of COPD (AECOPD) are associated with acute inflammation and infection, increase in the rates of morbidity and mortality.… read more here.
Keywords: proteins involved; cholesterol metabolism; network analysis; platelet degranulation ... See more keywords
Platelet degranulation and bleeding phenotype in a large cohort of Von Willebrand disease patients
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DOI: 10.1111/bjh.18145
Abstract: Von Willebrand disease (VWD) is a bleeding disorder caused by quantitative (type 1 or 3) or qualitative (type 2A/2B/2M/2N) defects of circulating von Willebrand factor (VWF). Circulating VWF levels not always fully explain bleeding phenotypes,… read more here.
Keywords: platelet degranulation; willebrand; willebrand disease; large cohort ... See more keywords