Chimeric antigen receptor‐modified T‐cell therapy for platelet‐derived growth factor receptor α‐positive rhabdomyosarcoma
Sign Up to like & getrecommendations! Published in 2020 at "Cancer"
DOI: 10.1002/cncr.32764
Abstract: New immunotherapeutic approaches are urgently needed for metastatic rhabdomyosarcoma, which is associated with poor survival and unsatisfactory treatment outcomes. Platelet‐derived growth factor receptor α (PDGFRA) plays an essential role in the onset and development of… read more here.
Keywords: growth factor; rhabdomyosarcoma; receptor; factor receptor ... See more keywords
Correlation between platelet‐derived growth factor‐B gene polymorphism and coronary heart disease
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Clinical Laboratory Analysis"
DOI: 10.1002/jcla.24683
Abstract: The aim of the present work was to investigate the correlation of plasma platelet‐derived growth factor (PDGF)‐BB level and single nucleotide polymorphism (SNP, rs1800817 and rs2285094) of PDGF‐B gene with the onset and stability condition… read more here.
Keywords: coronary heart; correlation; growth factor; derived growth ... See more keywords
Platelet-derived growth factor receptor beta identifies mesenchymal stem cells with enhanced engraftment to tissue injury and pro-angiogenic property
Sign Up to like & getrecommendations! Published in 2017 at "Cellular and Molecular Life Sciences"
DOI: 10.1007/s00018-017-2641-7
Abstract: Mesenchymal stem cells (MSCs) are heterogeneous likely consisting of subpopulations with various therapeutic potentials. Here we attempted to acquire a subset of MSCs with enhanced effect in wound healing. We found that human placental MSCs… read more here.
Keywords: derived growth; mscs; stem cells; platelet derived ... See more keywords
Notch-HEY2 signaling pathway contributes to the differentiation of CD34+ hematopoietic-like stem cells from adult peripheral blood insulin-producing cells after the treatment with platelet-derived mitochondria
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Biology Reports"
DOI: 10.1007/s11033-020-05874-w
Abstract: Previous works characterized a novel cell population from adult human peripheral blood, designated peripheral blood insulin-producing cells (PB-IPC). PB-IPC displayed the pluripotent potential of differentiations after the treatment with platelet-derived mitochondria and gave rise to… read more here.
Keywords: treatment; derived mitochondria; signaling pathway; peripheral blood ... See more keywords
Ultrastructural and Molecular Characterization of Platelet-derived growth factor Beta-Positive Leptomeningeal Cells in the Adult Rat Brain
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Neurobiology"
DOI: 10.1007/s12035-019-01793-5
Abstract: The leptomeninges, referring to the arachnoid and pia mater and their projections into the perivascular compartments in the central nervous system, actively participate in diverse biological processes including fluid homeostasis, immune cell infiltrations, and neurogenesis,… read more here.
Keywords: pdgfr cells; factor beta; growth factor; pdgfr ... See more keywords
Ligand-based computational modelling of platelet-derived growth factor beta receptor leading to new angiogenesis inhibitory leads
Sign Up to like & getrecommendations! Published in 2017 at "Computational biology and chemistry"
DOI: 10.1016/j.compbiolchem.2017.10.003
Abstract: Platelet derived growth factor beta receptor (PDGFR- β) plays an important role in angiogenesis. PDGFR-β expression is correlated with increased vascularity and maturation of blood vessels in cancer. Pharmacophore modeling and quantitative structure-activity relationship (QSAR)… read more here.
Keywords: angiogenesis; factor beta; beta receptor; growth factor ... See more keywords
GW28-e0985 CD31+CD42b+Platelet-Derived Microparticles: A New Biomarker Associated With Coagulation In Patients With Hypertension And Hyperlipidemia?
Sign Up to like & getrecommendations! Published in 2017 at "Journal of the American College of Cardiology"
DOI: 10.1016/j.jacc.2017.07.509
Abstract: The aim of this study is to investigate the plasmatic count and percentage of platelet-derived microparticles (PMP) in patients with hypertension and hyperlipidemia. And the relationship between PMP and clinical characteristics. The study included 18… read more here.
Keywords: patients hypertension; hypertension hyperlipidemia; derived microparticles; platelet derived ... See more keywords
Association between arginase-containing platelet-derived microparticles and altered plasma arginine metabolism in polycystic ovary syndrome.
Sign Up to like & getrecommendations! Published in 2019 at "Metabolism: clinical and experimental"
DOI: 10.1016/j.metabol.2018.10.008
Abstract: BACKGROUND Polycystic ovary syndrome (PCOS) is an endocrine and metabolic disease associated with insulin resistance and increased risk of cardiovascular diseases. However, a biomarker for potential cardiovascular disease in PCOS patients is not available. MATERIALS… read more here.
Keywords: polycystic ovary; arginase; ovary syndrome; derived microparticles ... See more keywords
Can intra-articular injection of freeze-dried platelet-derived factor concentrate regenerate articular cartilage in the knee joint?
Sign Up to like & getrecommendations! Published in 2019 at "Regenerative Therapy"
DOI: 10.1016/j.reth.2019.03.005
Abstract: Freeze-drying methods not only enable the delivery of growth factors using platelets, but also extend the shelf-life of platelet concentrates. The present study shows the clinical results of treating knee osteoarthritis with freeze-dried platelet-derived factor… read more here.
Keywords: dried platelet; freeze dried; derived factor; platelet ... See more keywords
Discovery of Potent and Orally Bioavailable Platelet-Derived Growth Factor Receptor (PDGFR) Inhibitors for the Treatment of Osteosarcoma.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.1c01732
Abstract: Platelet-derived growth factor receptors (PDGFRs) are now considered promising targets for the treatment of osteosarcoma. Herein, the design, synthesis, and structure-activity relationships (SAR) of novel pyrimidine-2,4-diamine derivatives that selectively inhibit PDGFRα/β kinases have been studied.… read more here.
Keywords: treatment osteosarcoma; pdgfr; growth factor; derived growth ... See more keywords
Enhancing Vascularization through the Controlled Release of Platelet-Derived Growth Factor-BB.
Sign Up to like & getrecommendations! Published in 2017 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.6b13760
Abstract: Using delivery systems to control the in vivo release of growth factors (GFs) for tissue engineering applications is extremely desirable as the clinical use of GFs is limited by their fast in vivo turnover. Hence,… read more here.
Keywords: vivo; growth factor; growth; platelet derived ... See more keywords