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   Articles with "platelet dysfunction" as a keyword



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Platelet aggregometry cannot identify uremic platelet dysfunction in heart failure patients prior to cardiac surgery

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recommendations! Published in 2017 at "Journal of Clinical Laboratory Analysis"

DOI: 10.1002/jcla.22084

Abstract: Patients with heart failure often have concomitant renal disease which can result in uremic platelet dysfunction. Determining whether uremia has affected platelets by platelet aggregometry can be challenging in these patients since they are often… read more here.

Keywords: platelet; uremic platelet; platelet dysfunction; heart failure ... See more keywords
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Atypical late diagnosis of Noonan syndrome revealed by bleedings due to platelet dysfunction

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recommendations! Published in 2021 at "Journal of Thrombosis and Thrombolysis"

DOI: 10.1007/s11239-021-02547-8

Abstract: Platelets play a crucial role in primary haemostasis as they adhere at the site of vascular breachs, aggregate and initiate clot formation [1]. Inherited platelet function disorders (IPFD) comprise a rare and heterogeneous group of… read more here.

Keywords: noonan syndrome; diagnosis; platelet dysfunction; platelet ... See more keywords
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Relationship of Coagulopathy and Platelet Dysfunction to Transfusion Needs After Traumatic Brain Injury

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recommendations! Published in 2018 at "Neurocritical Care"

DOI: 10.1007/s12028-017-0485-5

Abstract: BackgroundCoagulopathy and platelet dysfunction commonly develop after traumatic brain injury (TBI). Thromboelastography (TEG) and platelet function assays (PFAs) are often performed at the time of admission; however, their roles in assessing post-TBI coagulopathy have not… read more here.

Keywords: traumatic brain; platelet dysfunction; tbi; brain injury ... See more keywords
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Platelet dysfunction on thromboelastogram is associated with severity of blunt traumatic brain injury.

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recommendations! Published in 2019 at "American journal of surgery"

DOI: 10.1016/j.amjsurg.2019.09.024

Abstract: BACKGROUND Platelet dysfunction associated with isolated traumatic brain injury (TBI) can be measured using thromboelastography-platelet mapping (TEG-PM). We hypothesized that platelet dysfunction can be detected after blunt TBI, and the degree of dysfunction is associated… read more here.

Keywords: dysfunction; platelet dysfunction; severity; blunt ... See more keywords
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Platelet dysfunction in patients with traumatic intracranial hemorrhage: Do desmopressin and platelet therapy help or harm?

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recommendations! Published in 2021 at "American journal of surgery"

DOI: 10.1016/j.amjsurg.2021.07.050

Abstract: BACKGROUND Pre-injury anti-platelet use has been associated with increased risk of progression of traumatic intracranial hemorrhage (TICH) and worse outcomes. VerifyNow® assays assess platelet inhibition due to aspirin/clopidogrel. This study assesses the outcomes of patients… read more here.

Keywords: intracranial hemorrhage; platelet dysfunction; traumatic intracranial; platelet ... See more keywords
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Platelet dysfunction during pediatric cardiac ECMO

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recommendations! Published in 2020 at "Progress in Pediatric Cardiology"

DOI: 10.1016/j.ppedcard.2019.101187

Abstract: Abstract Pediatric extracorporeal membrane oxygenation (ECMO) is used for respiratory and cardiac failure refractory to conventional treatment. ECMO has been increasingly utilized for pediatric cardiac patients. Despite improved mortality, complications during and after ECMO are… read more here.

Keywords: dysfunction pediatric; ecmo; platelet dysfunction; pediatric cardiac ... See more keywords
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Cobimetinib and trametinib inhibit platelet MEK but do not cause platelet dysfunction

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recommendations! Published in 2019 at "Platelets"

DOI: 10.1080/09537104.2018.1514107

Abstract: Abstract The MEK inhibitors cobimetinib and trametinib are used in combination with BRAF inhibitors to treat metastatic melanoma but increase rates of hemorrhage relative to BRAF inhibitors alone. Platelets express several members of the MAPK… read more here.

Keywords: mek inhibitors; platelet dysfunction; mek; platelet ... See more keywords
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ETV6-related thrombocytopenia and platelet dysfunction

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recommendations! Published in 2020 at "Platelets"

DOI: 10.1080/09537104.2020.1760229

Abstract: Abstract We and others recently described families with germline heterozygote mutations in ETV6 leading to autosomal dominant highly penetrant thrombocytopenia, red cell macrocytosis and predisposition to leukemia.The bone marrow of affected individuals shows erythroid dysplasia… read more here.

Keywords: etv6 related; thrombocytopenia platelet; platelet dysfunction; etv6 mutations ... See more keywords
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Platelet dysfunction following Traumatic Brain Injury: A Review.

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recommendations! Published in 2020 at "Journal of neurotrauma"

DOI: 10.1089/neu.2020.7301

Abstract: Coagulopathy is a known sequela of traumatic brain injury (TBI) and can lead to increased morbidity and mortality. Platelet dysfunction has been identified as one of several etiologies of coagulopathy following TBI and has been… read more here.

Keywords: traumatic brain; platelet dysfunction; review; injury ... See more keywords
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PLATELET FUNCTION IN TRAUMA: IS CURRENT TECHNOLOGY IN FUNCTION TESTING MISSING THE MARK IN INJURED PATIENTS?

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recommendations! Published in 2022 at "Shock"

DOI: 10.1097/shk.0000000000001948

Abstract: ABSTRACT Platelets are subcellular anucleate components of blood primarily responsible for initiating and maintaining hemostasis. After injury to a blood vessel, platelets can be activated via several pathways, resulting in changed shape, adherence to the… read more here.

Keywords: function; trauma; platelet dysfunction; platelet ... See more keywords
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Goal-directed platelet transfusions correct platelet dysfunction and may improve survival in patients with severe traumatic brain injury

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recommendations! Published in 2018 at "Journal of Trauma and Acute Care Surgery"

DOI: 10.1097/ta.0000000000002047

Abstract: BACKGROUND Platelet dysfunction, defined as adenosine diphosphate inhibition greater than 60% on thromboelastogram, is an independent predictor of increased mortality in patients with severe traumatic brain injury (TBI). We changed our practice to transfuse platelets… read more here.

Keywords: patients severe; platelet transfusion; platelet dysfunction; severe tbi ... See more keywords