Platelet activation and placenta-mediated adverse pregnancy outcomes: an ancillary study to the EAGeR trial.
Sign Up to like & getrecommendations! Published in 2020 at "American journal of obstetrics and gynecology"
DOI: 10.1016/j.ajog.2020.05.026
Abstract: BACKGROUND Platelet activation may play a role in the pathophysiology of placenta-mediated obstetric complications, as evidenced by the efficacy of aspirin for preventing preeclampsia, but published data regarding the relationship between biomarkers for platelet activation… read more here.
Keywords: pregnancy; aspirin; platelet activation; platelet factor ... See more keywords
Platelet Factor 4 Interactions with Short Heparin Oligomers: Implications for Folding and Assembly.
Sign Up to like & getrecommendations! Published in 2020 at "Biophysical journal"
DOI: 10.1016/j.bpj.2020.04.012
Abstract: Association of platelet factor 4 (PF4) with heparin is a first step in formation of aggregates implicated in the development of heparin-induced thrombocytopenia (HIT), a potentially fatal immune disorder affecting 1-5% of patients receiving heparin.… read more here.
Keywords: heparin; short heparin; heparin oligomers; platelet factor ... See more keywords
In platelet single donor apheresis, platelet factor 4 levels correlated with donor’s age and decreased during storage
Sign Up to like & getrecommendations! Published in 2024 at "Scientific Reports"
DOI: 10.1038/s41598-024-56826-4
Abstract: The human population is ageing worldwide. The World Health Organization estimated that the world’s population of people aged 60 years and older will increase to at least 30%, coinciding with a growing frequency of cognitive… read more here.
Keywords: age; platelet; factor; storage ... See more keywords
Molecular architecture and platelet-activating properties of small immune complexes assembled on heparin and platelet factor 4
Sign Up to like & getrecommendations! Published in 2024 at "Communications Biology"
DOI: 10.1038/s42003-024-05982-4
Abstract: Heparin-induced thrombocytopenia (HIT) is an adverse reaction to heparin leading to a reduction in circulating platelets with an increased risk of thrombosis. It is precipitated by polymerized immune complexes consisting of pathogenic antibodies that recognize… read more here.
Keywords: pf4; platelet; immune complexes; assembled heparin ... See more keywords
Platelet Factor 4 and Longevity of Patients with Essential Thromobocythemia: An Example of Antagonistic Pathogenic Pleiotropy
Sign Up to like & getrecommendations! Published in 2024 at "Rejuvenation Research"
DOI: 10.1089/rej.2023.0066
Abstract: This article presents the concept of Antagonistic Pathogenic Pleiotropy, in which an abnormality that causes a specific pathology can simultaneously reduce other morbidities through unrelated mechanisms, resulting in the pathology causing less morbidity or mortality… read more here.
Keywords: platelet factor; pathology; antagonistic pathogenic; pathogenic pleiotropy ... See more keywords
Cellular contributions to the pathogenesis of anti-platelet factor 4 disorders.
Sign Up to like & getrecommendations! Published in 2025 at "Current opinion in hematology"
DOI: 10.1097/moh.0000000000000900
Abstract: PURPOSE OF REVIEW Anti-platelet factor 4 (PF4) disorders, including heparin-induced thrombocytopenia (HIT) and vaccine-induced immune thrombocytopenia and thrombosis (VITT), and emerging disorders such as VITT-like monoclonal gammopathy of thrombotic significance (MGTS), are monoclonal antibody-mediated and… read more here.
Keywords: pf4 disorders; factor; pathogenesis anti; platelet factor ... See more keywords
The complicated relationships of heparin‐induced thrombocytopenia and platelet factor 4 antibodies with COVID‐19
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Laboratory Hematology"
DOI: 10.1111/ijlh.13582
Abstract: COVID‐19 (coronavirus disease 2019) represents a prothrombotic disorder, and there have been several reports of platelet factor 4/heparin antibodies being present in COVID‐19‐infected patients. This has thus been identified in some publications as representing a… read more here.
Keywords: heparin induced; platelet factor; induced thrombocytopenia; platelet ... See more keywords
Platelet factor 4 triggers thrombo-inflammation by bridging innate and adaptive immunity.
Sign Up to like & getrecommendations! Published in 2023 at "International journal of laboratory hematology"
DOI: 10.1111/ijlh.14075
Abstract: Platelet factor 4 (PF4, synonym: CXCL4) is an evolutionary old chemokine with proposed roles in hemostasis and antimicrobial defense. In addition, PF4 has attracted considerable attention as a crucial mediator of one of the most… read more here.
Keywords: hit vitt; vitt antibodies; pf4; platelet ... See more keywords
Chronic periodontitis is associated with platelet factor 4 (PF4) secretion: A pilot study
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Clinical Periodontology"
DOI: 10.1111/jcpe.12771
Abstract: AIM Platelets contribute to chronic inflammation, but their role in periodontitis is not well understood. The aim of this study was to compare platelet recruitment and activation in healthy and inflamed periodontium. MATERIALS AND METHODS… read more here.
Keywords: factor pf4; periodontitis associated; gcf; platelet factor ... See more keywords
Cellular immune responses to platelet factor 4 and heparin complexes in patients with heparin‐induced thrombocytopenia
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Thrombosis and Haemostasis"
DOI: 10.1111/jth.14132
Abstract: Essentials The immunogenesis of Heparin‐induced thrombocytopenia (HIT) is not well understood. Immunization to platelet factor 4 (PF4)‐heparin occurs early in life, before any heparin exposure. PF4 and PF4‐heparin complexes induce the proliferation of CD14+ cells.… read more here.
Keywords: heparin; heparin complexes; induced thrombocytopenia; heparin induced ... See more keywords
Platelet factor 4 enhances CD4+ T effector memory cell responses via Akt‐PGC1α‐TFAM signaling‐mediated mitochondrial biogenesis
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Thrombosis and Haemostasis"
DOI: 10.1111/jth.15005
Abstract: Cell metabolism drives T cell functions, while platelets regulate overall CD4+ T cell immune responses. read more here.
Keywords: factor enhances; effector memory; enhances cd4; cd4 effector ... See more keywords