Platelet activation and placenta-mediated adverse pregnancy outcomes: an ancillary study to the EAGeR trial.
Sign Up to like & getrecommendations! Published in 2020 at "American journal of obstetrics and gynecology"
DOI: 10.1016/j.ajog.2020.05.026
Abstract: BACKGROUND Platelet activation may play a role in the pathophysiology of placenta-mediated obstetric complications, as evidenced by the efficacy of aspirin for preventing preeclampsia, but published data regarding the relationship between biomarkers for platelet activation… read more here.
Keywords: pregnancy; aspirin; platelet activation; platelet factor ... See more keywords
Platelet Factor 4 Interactions with Short Heparin Oligomers: Implications for Folding and Assembly.
Sign Up to like & getrecommendations! Published in 2020 at "Biophysical journal"
DOI: 10.1016/j.bpj.2020.04.012
Abstract: Association of platelet factor 4 (PF4) with heparin is a first step in formation of aggregates implicated in the development of heparin-induced thrombocytopenia (HIT), a potentially fatal immune disorder affecting 1-5% of patients receiving heparin.… read more here.
Keywords: heparin; short heparin; heparin oligomers; platelet factor ... See more keywords
The complicated relationships of heparin‐induced thrombocytopenia and platelet factor 4 antibodies with COVID‐19
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Laboratory Hematology"
DOI: 10.1111/ijlh.13582
Abstract: COVID‐19 (coronavirus disease 2019) represents a prothrombotic disorder, and there have been several reports of platelet factor 4/heparin antibodies being present in COVID‐19‐infected patients. This has thus been identified in some publications as representing a… read more here.
Keywords: heparin induced; platelet factor; induced thrombocytopenia; platelet ... See more keywords
Platelet factor 4 triggers thrombo-inflammation by bridging innate and adaptive immunity.
Sign Up to like & getrecommendations! Published in 2023 at "International journal of laboratory hematology"
DOI: 10.1111/ijlh.14075
Abstract: Platelet factor 4 (PF4, synonym: CXCL4) is an evolutionary old chemokine with proposed roles in hemostasis and antimicrobial defense. In addition, PF4 has attracted considerable attention as a crucial mediator of one of the most… read more here.
Keywords: hit vitt; vitt antibodies; pf4; platelet ... See more keywords
Chronic periodontitis is associated with platelet factor 4 (PF4) secretion: A pilot study
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Clinical Periodontology"
DOI: 10.1111/jcpe.12771
Abstract: AIM Platelets contribute to chronic inflammation, but their role in periodontitis is not well understood. The aim of this study was to compare platelet recruitment and activation in healthy and inflamed periodontium. MATERIALS AND METHODS… read more here.
Keywords: factor pf4; periodontitis associated; gcf; platelet factor ... See more keywords
Cellular immune responses to platelet factor 4 and heparin complexes in patients with heparin‐induced thrombocytopenia
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Thrombosis and Haemostasis"
DOI: 10.1111/jth.14132
Abstract: Essentials The immunogenesis of Heparin‐induced thrombocytopenia (HIT) is not well understood. Immunization to platelet factor 4 (PF4)‐heparin occurs early in life, before any heparin exposure. PF4 and PF4‐heparin complexes induce the proliferation of CD14+ cells.… read more here.
Keywords: heparin; heparin complexes; induced thrombocytopenia; heparin induced ... See more keywords
Platelet factor 4 enhances CD4+ T effector memory cell responses via Akt‐PGC1α‐TFAM signaling‐mediated mitochondrial biogenesis
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Thrombosis and Haemostasis"
DOI: 10.1111/jth.15005
Abstract: Cell metabolism drives T cell functions, while platelets regulate overall CD4+ T cell immune responses. read more here.
Keywords: factor enhances; effector memory; enhances cd4; cd4 effector ... See more keywords
Evaluation of laboratory assays for anti‐Platelet Factor 4 antibodies after ChAdOx1 nCOV‐19 vaccination
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Thrombosis and Haemostasis"
DOI: 10.1111/jth.15362
Abstract: Vaccine‐induced immune thrombocytopenia and thrombosis (VITT) following ChAdOx1 nCOV‐19 vaccine has been described, associated with unusual site thrombosis, thrombocytopenia, raised D‐dimer, and high‐titer immunoglobulin‐G (IgG) class anti‐platelet factor 4 (PF4) antibodies. Enzyme‐linked immunosorbent assays (ELISA)… read more here.
Keywords: anti platelet; chadox1 ncov; evaluation laboratory; platelet factor ... See more keywords
Potential Anionic Substances Binding to Platelet Factor 4 in Vaccine-Induced Thrombotic Thrombocytopenia of ChAdOx1-S Vaccine for SARS-CoV-2
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2021.782335
Abstract: Recent reports of rare ChAdOx1-S vaccine-related venous thrombosis led to the suspension of its usage in several countries. Vaccine-induced thrombotic thrombocytopenia (VITT) is characterized by thrombocytopenia and thrombosis in association with anti-platelet factor 4 (PF4)… read more here.
Keywords: thrombotic thrombocytopenia; platelet factor; induced thrombotic; chadox1 vaccine ... See more keywords
Interactions of marine sulfated glycans with antithrombin and platelet factor 4
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Molecular Biosciences"
DOI: 10.3389/fmolb.2022.954752
Abstract: The molecular interactions of sulfated glycans, such as heparin, with antithrombin (AT) and platelet factor 4 (PF4) are essential for certain biological events such as anticoagulation and heparin induced thrombocytopenia (HIT). In this study, a… read more here.
Keywords: platelet factor; antithrombin platelet; sulfated glycans; molecular weight ... See more keywords
Evaluating the immunogenicity of heparin and heparin derivatives by measuring their binding to platelet factor 4 using biolayer interferometry
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Molecular Biosciences"
DOI: 10.3389/fmolb.2022.966754
Abstract: Heparin (HP) is a polysaccharide that is widely used in the clinic as an anticoagulant. A major side effect associated with HP is the heparin-induced thrombocytopenia (HIT), which is initiated by the immune response to… read more here.
Keywords: heparin; immunogenicity; biolayer interferometry; platelet factor ... See more keywords