Platelet Function Tests: Preanalytical Variables, Clinical Utility, Advantages, and Disadvantages.
Sign Up to like & getrecommendations! Published in 2017 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-7196-1_24
Abstract: Platelet function tests are mainly used in the diagnostic work-up of platelet disorders. During the last decade, the additional use of platelet function tests to evaluate the effect of antiplatelet therapy has also emerged in… read more here.
Keywords: use platelet; platelet function; function tests; function ... See more keywords
Point-of-care platelet function tests: relevance to arterial thrombosis and opportunities for improvement
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DOI: 10.1007/s11239-020-02170-z
Abstract: Studies using whole blood platelet aggregometry as a laboratory research tool, provided important insights into the mechanism and modulators of platelet aggregation. Subsequently, a number of point-of-care (POC) platelet function tests (PFTs) were developed for… read more here.
Keywords: point care; platelet function; thrombosis; function tests ... See more keywords
Estimating Short- and Long-term Reference Change Values and Index of Individuality for Tests of Platelet Function.
Sign Up to like & getrecommendations! Published in 2019 at "Clinical biochemistry"
DOI: 10.1016/j.clinbiochem.2019.10.001
Abstract: BACKGROUND In order to manage risks of bleeding and thrombosis after some surgical procedures, platelet function is often measured repeatedly over days or weeks using laboratory tests of platelet function. To interpret test results in… read more here.
Keywords: platelet function; long term; change; reference ... See more keywords
A comparison of three platelet function tests in ischemic stroke patients with antiplatelet therapy
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Clinical Neuroscience"
DOI: 10.1016/j.jocn.2020.06.004
Abstract: Predicting the effectiveness of antiplatelet drugs is critical to precision antiplatelet therapy. However, there is a lack of an acceptable method, although there are a variety of methods for detecting platelet function. In this study,… read more here.
Keywords: ischemic stroke; platelet function; stroke patients; function ... See more keywords
p47phox deficiency impairs platelet function and protects mice against arterial and venous thrombosis
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DOI: 10.1016/j.redox.2020.101569
Abstract: NADPH oxidase-derived reactive oxygen species (ROS) regulates platelet function and thrombosis. It remains controversial regarding NOX2’s role in platelet function. As a regulatory subunit for NOX2, whether p47phox regulates platelet function remains unclear. Our study… read more here.
Keywords: platelet function; p47phox; arterial venous; p47phox deficiency ... See more keywords
Comparison of Multiplate and VerifyNow platelet function tests in predicting clinical outcome in patients with acute coronary syndromes.
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DOI: 10.1016/j.thromres.2017.02.006
Abstract: INTRODUCTION This study examined the ability of two widely used "point of care" platelet function assays, VerifyNow and Multiplate, to predict adverse outcomes in patients with acute coronary syndromes (ACS). METHODS We examined platelet reactivity… read more here.
Keywords: platelet function; patients acute; mace; platelet ... See more keywords
ANTARCTIC: platelet function testing to adjust therapy
Sign Up to like & getrecommendations! Published in 2017 at "The Lancet"
DOI: 10.1016/s0140-6736(17)30780-8
Abstract: www.thelancet.com Vol 389 March 25, 2017 1193 in ANTARCTIC was de-intensification to clopidogrel in an attempt to reduce bleeding. In the GENERATIONS and TRILOGY ACS trials, the bleeding rates were the same between the prasugrel… read more here.
Keywords: antarctic platelet; function testing; platelet function; testing adjust ... See more keywords
Platelet behaviour on von Willebrand Factor changes in pregnancy: Consequences of haemodilution and intrinsic changes in platelet function
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DOI: 10.1038/s41598-017-06959-6
Abstract: Platelet function in pregnancy is poorly understood. Previous studies of platelet function in pregnancy have used non-physiological assays of platelet function with conflicting results. This study using a physiological assay of platelet function investigated platelet… read more here.
Keywords: pregnancy; platelet function; von willebrand; function ... See more keywords
Loss of the mitochondrial kinase PINK1 does not alter platelet function
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DOI: 10.1038/s41598-018-32716-4
Abstract: PTEN-induced putative kinase (PINK) 1 is regarded as a master regulator of cellular mitophagy such that loss of function mutations contribute to early onset Parkinson’s disease, through aberrant mitochondrial control and function. Mitochondrial function is… read more here.
Keywords: platelet function; kinase; pink1; function ... See more keywords
Laser speckle decorrelation time-based platelet function testing in microfluidic system
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DOI: 10.1038/s41598-019-52953-5
Abstract: Platelet aggregation and adhesion are critically involved in both normal hemostasis and thrombosis during vascular injury. Before any surgery, it is important to identify the number of platelets and their functionality to reduce the risk… read more here.
Keywords: platelet function; decorrelation time; whole blood; blood ... See more keywords
Inhibition of HIF prolyl hydroxylase modulates platelet function.
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DOI: 10.1055/a-1837-7797
Abstract: Hypoxia-inducible factors-1α (HIF-1α) involves in redox reaction. Considering the role of reactive oxygen species (ROS) in platelet function, whether it regulates platelet function remains unclear. Using an inhibitor of HIF prolyl hydroxylase IOX-2, we intend… read more here.
Keywords: function; prolyl hydroxylase; hif prolyl; hif ... See more keywords