Proteomic analysis of MSC‐derived apoptotic vesicles identifies Fas inheritance to ameliorate haemophilia a via activating platelet functions
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Extracellular Vesicles"
DOI: 10.1002/jev2.12240
Abstract: Abstract Apoptotic vesicles (apoVs) are apoptotic cell‐derived nanosized vesicles that play a crucial role in multiple pathophysiological settings. However, their detailed characteristics, specific surface markers, and biological properties are not fully elucidated. In this study,… read more here.
Keywords: apoptotic vesicles; msc; ameliorate haemophilia; msc derived ... See more keywords
Non-genomic effects of the Pregnane X Receptor negatively regulate platelet functions, thrombosis and haemostasis
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-53218-x
Abstract: The pregnane X receptor (PXR) is a nuclear receptor (NR), involved in the detoxification of xenobiotic compounds. Recently, its presence was reported in the human vasculature and its ligands were proposed to exhibit anti-atherosclerotic effects.… read more here.
Keywords: pregnane receptor; platelet functions; receptor; platelet ... See more keywords
PIKfyve-Dependent Phosphoinositide Dynamics in Megakaryocyte/Platelet Granule Integrity and Platelet Functions
Sign Up to like & getrecommendations! Published in 2022 at "Arteriosclerosis, Thrombosis, and Vascular Biology"
DOI: 10.1161/atvbaha.122.317559
Abstract: Background: Secretory granules are key elements for platelet functions. Their biogenesis and integrity are regulated by fine-tuned mechanisms that need to be fully characterized. Here, we investigated the role of the phosphoinositide 5-kinase PIKfyve and… read more here.
Keywords: ptdins5p ptdins; granule integrity; granule; platelet functions ... See more keywords
Tyrosine Kinase Inhibitor–Associated Platelet Dysfunction: Does This Need to Have a Significant Clinical Impact?
Sign Up to like & getrecommendations! Published in 2019 at "Clinical and Applied Thrombosis/Hemostasis"
DOI: 10.1177/1076029619866925
Abstract: The management of chronic myeloid leukemia (CML) entirely changed after the emergence of tyrosine kinase inhibitors (TKIs). In the era of TKIs, the 10-year overall survival now exceeds 80%, and the prevalence of patients receiving… read more here.
Keywords: platelet function; platelet functions; platelet dysfunction; tkis ... See more keywords
Effects of Nanoceria on Human Platelet Functions and Blood Coagulation
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Nanomedicine"
DOI: 10.2147/ijn.s332909
Abstract: Purpose Cerium oxide nanoparticles (nanoceria) exist in either 3+ or 4+ oxidation state with interesting redox properties and exhibit both oxidant and antioxidant attributes based on concentration, environment and pH. Thanks to their wide spread… read more here.
Keywords: effects nanoceria; blood; blood coagulation; platelet ... See more keywords