Syntaxin 12 and COMMD3 are new factors that function with VPS33B in the biogenesis of platelet α-granules.
Sign Up to like & getrecommendations! Published in 2021 at "Blood"
DOI: 10.1182/blood.2021012056
Abstract: Platelet a-granules regulate hemostasis and myriad other physiological processes but their biogenesis is unclear. Mutations in only three proteins are known to cause a-granule defects and bleeding disorders in humans. Two such proteins, VPS16B and… read more here.
Keywords: platelet granules; vps16b vps33b; granule; biogenesis ... See more keywords
The life cycle of platelet granules
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DOI: 10.12688/f1000research.13283.1
Abstract: Platelet granules are unique among secretory vesicles in both their content and their life cycle. Platelets contain three major granule types—dense granules, α-granules, and lysosomes—although other granule types have been reported. Dense granules and α-granules… read more here.
Keywords: life cycle; dense granules; platelet granules; platelet ... See more keywords