The proteomic and particle composition of human platelet lysate for cell therapy products
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.30310
Abstract: Following health agencies warning, the use of animal origin supplements should be avoided in biological products proposed as therapy in humans. Platelet lysate and several other growth factors sources are alternatives to replace fetal calf… read more here.
Keywords: cell; growth; therapy; particle ... See more keywords
Novel therapeutic approaches in utilizing platelet lysate in regenerative medicine: Are we ready for clinical use?
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.28496
Abstract: Hemoderivative materials are used to treat different diseases. These derivatives include platelet‐rich plasma, serum, platelet gel, and platelet lysate (PL). Among them, PL contains more growth factors than the others and its production is inexpensive… read more here.
Keywords: growth factor; medicine; platelet lysate; growth ... See more keywords
Primary 3D Culture of Human Thyroid Follicle-Like Structures in Platelet Lysate-Based Gel
Sign Up to like & getrecommendations! Published in 2020 at "Bulletin of Experimental Biology and Medicine"
DOI: 10.1007/s10517-020-04930-6
Abstract: The results of 3D culturing of human thyroid follicle-like structures in a gel based on platelet lysate at the gel-air interface are presented. During culturing up to 4 months, no new follicle-like structures were formed… read more here.
Keywords: human thyroid; follicle like; like structures; thyroid follicle ... See more keywords
A novel dressing for the combined delivery of platelet lysate and vancomycin hydrochloride to chronic skin ulcers: Hyaluronic acid particles in alginate matrices
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Pharmaceutical Sciences"
DOI: 10.1016/j.ejps.2018.03.024
Abstract: &NA; The aim of the present work was to develop a medication allowing for the combined delivery of platelet lysate (PL) and an anti‐infective model drug, vancomycin hydrochloride (VCM), to chronic skin ulcers. A simple… read more here.
Keywords: combined delivery; delivery platelet; skin; platelet lysate ... See more keywords
Differentiation of cardiomyocyte-like cells from human amniotic fluid mesenchymal stem cells by combined induction with human platelet lysate and 5-azacytidine
Sign Up to like & getrecommendations! Published in 2020 at "Heliyon"
DOI: 10.1016/j.heliyon.2020.e04844
Abstract: Human amniotic fluid mesenchymal stem cells (hAF-MSCs) have been shown to be effective in the treatment of many diseases. Platelet lysate (PL) contains multiple growth and differentiation factors; therefore, it can be used as a… read more here.
Keywords: fluid mesenchymal; differentiation; human amniotic; amniotic fluid ... See more keywords
Platelet lysate enhances synovial fluid multipotential stromal cells functions: Implications for therapeutic use.
Sign Up to like & getrecommendations! Published in 2018 at "Cytotherapy"
DOI: 10.1016/j.jcyt.2017.12.003
Abstract: BACKGROUND AIMS Although intra-articular injection of platelet products is increasingly used for joint regenerative approaches, there are few data on their biological effects on joint-resident multipotential stromal cells (MSCs), which are directly exposed to the… read more here.
Keywords: stromal cells; synovial fluid; mscs; platelet lysate ... See more keywords
Characterization of a pathogen reduced human platelet lysate
Sign Up to like & getrecommendations! Published in 2018 at "Cytotherapy"
DOI: 10.1016/j.jcyt.2018.02.168
Abstract: As more manufactured cellular therapies move into clinical use, there is an increasing call for cell culture media supplements that are of high quality, compatible with different cell types, and not supply-limited. Human platelet lysate… read more here.
Keywords: pathogen reduced; characterization pathogen; human platelet; platelet lysate ... See more keywords
A highly standardized and characterized human platelet lysate for efficient and reproducible expansion of human bone marrow mesenchymal stromal cells.
Sign Up to like & getrecommendations! Published in 2019 at "Cytotherapy"
DOI: 10.1016/j.jcyt.2019.04.053
Abstract: BACKGROUND Human platelet lysate (hPL) represents a powerful alternative to fetal bovine serum (FBS) for human mesenchymal stromal cell (hMSC) expansion. However, the large variability in hPL sources and production protocols gives rise to discrepancies… read more here.
Keywords: 200 dhpl; mesenchymal stromal; standardization; expansion ... See more keywords
Gamma irradiated human platelet lysate as a serum substitute for ex vivo expansion of immune cells
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DOI: 10.1016/j.jcyt.2020.03.272
Abstract: Background & Aim Adoptive immunotherapy is emerged as one of the leading treatments in cancer. The clinical applications require ex vivo expansion of lymphocytes to therapeutic doses in a timely manner under strict cGMP compliance.… read more here.
Keywords: vivo expansion; expansion; hpl; human platelet ... See more keywords
Platelet lysate enhances equine skeletal muscle regeneration in a bupivacaine-induced muscle injury model.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of equine veterinary science"
DOI: 10.1016/j.jevs.2022.103892
Abstract: This study aimed to verify the effects of platelet lysate (PL) administration on the repair of injured horse tissue. Skeletal muscle injuries were induced in 26 Thoroughbreds by bupivacaine administration. PL or saline was administered… read more here.
Keywords: platelet lysate; muscle; injury; administration ... See more keywords
Platelet lysate reduces the chondrocyte dedifferentiation during in vitro expansion: Implications for cartilage tissue engineering.
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DOI: 10.1016/j.rvsc.2020.08.017
Abstract: In vitro studies have demonstrated that platelet lysate (PL) can serve as an alternative to platelet-rich plasma (PRP) to sustain chondrocyte proliferation and production of extracellular matrix components in chondrocytes. The present study aimed to… read more here.
Keywords: vitro expansion; proliferation; platelet lysate; platelet ... See more keywords