P2Y12 Inhibition Suppresses Proinflammatory Platelet–Monocyte Interactions
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DOI: 10.1055/s-0042-1758655
Abstract: BACKGROUND  Monocyte-platelet aggregates (MPAs) represent the crossroads between thrombosis and inflammation, and targeting this axis may suppress thromboinflammation. While antiplatelet therapy (APT) reduces platelet-platelet aggregation and thrombosis, its effects on MPA and platelet effector properties… read more here.
Keywords: monocyte; platelet monocyte; proinflammatory platelet; platelet ... See more keywords
Elevation of Platelet and Monocyte Activity Markers of Atherosclerosis in Haemodialysis Patients Compared to Peritoneal Dialysis Patients
Sign Up to like & getrecommendations! Published in 2017 at "Mediators of Inflammation"
DOI: 10.1155/2017/8506072
Abstract: Purpose The predominant cause of mortality in dialysis patients are cardiovascular events. Platelet and monocyte activity markers play an important role in cardiovascular mortality and were assessed and related to dialysis quality criteria in haemodialysis… read more here.
Keywords: monocyte activity; platelet monocyte; activity markers; dialysis patients ... See more keywords
Platelet-, monocyte-derived and tissue factor-carrying circulating microparticles are related to acute myocardial infarction severity
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DOI: 10.1371/journal.pone.0172558
Abstract: Objective Circulating microparticles (cMPs) are phospholipid-rich vesicles released from cells when activated or injured, and contribute to the formation of intracoronary thrombi. Tissue factor (TF, CD142) is the main trigger of fibrin formation and TF-carrying… read more here.
Keywords: platelet monocyte; tissue factor; severity; circulating microparticles ... See more keywords
Increased platelet activation and lower platelet-monocyte aggregates in COVID-19 patients with severe pneumonia
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DOI: 10.1371/journal.pone.0282785
Abstract: Background The increased procoagulant platelets and platelet activation are associated with thrombosis in COVID-19. In this study, we investigated platelet activation in COVID-19 patients and their association with other disease markers. Methods COVID-19 patients were… read more here.
Keywords: severe pneumonia; covid patients; pneumonia; platelet monocyte ... See more keywords
Platelet-monocyte aggregates: molecular mediators of thromboinflammation
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Cardiovascular Medicine"
DOI: 10.3389/fcvm.2023.960398
Abstract: Platelets, key facilitators of primary hemostasis and thrombosis, have emerged as crucial cellular mediators of innate immunity and inflammation. Exemplified by their ability to alter the phenotype and function of monocytes, activated platelets bind to… read more here.
Keywords: platelet monocyte; aggregates molecular; monocyte aggregates; platelet ... See more keywords