Rapamycin restrains platelet procoagulant responses via FKBP-mediated protection of mitochondrial integrity.
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DOI: 10.1016/j.bcp.2020.113975
Abstract: BACKGROUND AND PURPOSE Rapamycin is a potent immunosuppressant and anti-proliferative agent used clinically to prevent organ transplant rejection and for coating coronary stents to counteract restenosis. Rapamycin complexes with the immunophilin FKBP12, which subsequently binds… read more here.
Keywords: platelet procoagulant; procoagulant responses; integrity; effect rapamycin ... See more keywords
Carbonic Anhydrase Inhibitors suppress platelet procoagulant responses and in vivo thrombosis
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DOI: 10.1080/09537104.2019.1709632
Abstract: Abstract Carbonic anhydrase (CA) inhibitors have a long history of safe clinical use as mild diuretics, in the treatment of glaucoma and for altitude sickness prevention. In this study, we aimed to determine if CA… read more here.
Keywords: anhydrase inhibitors; carbonic anhydrase; platelet procoagulant; thrombosis ... See more keywords