Myocardial infarction induces bone marrow megakaryocyte proliferation, maturation and platelet production.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2019.01.129
Abstract: Platelet, apart from its classic role of homeostasis, serves also as a crucial immune cell component that contributes to the aggravation of atherosclerosis. It has been reported that myocardial infarction (MI) triggers leukocytosis in the… read more here.
Keywords: myocardial infarction; platelet; platelet production; induces bone ... See more keywords
Phosphatidylinositol 3 monophosphate metabolizing enzymes in blood platelet production and in thrombosis.
Sign Up to like & getrecommendations! Published in 2019 at "Advances in biological regulation"
DOI: 10.1016/j.jbior.2019.100664
Abstract: Blood platelets, produced by the fragmentation of megakaryocytes, play a key role in hemostasis and thrombosis. Being implicated in atherothrombosis and other thromboembolic disorders, they represent a major therapeutic target for antithrombotic drug development. Several… read more here.
Keywords: production; metabolizing enzymes; platelet production; phosphatidylinositol monophosphate ... See more keywords
Modulation of megakaryopoiesis and platelet production during inflammation.
Sign Up to like & getrecommendations! Published in 2019 at "Thrombosis research"
DOI: 10.1016/j.thromres.2019.05.008
Abstract: Megakaryocytes (MKs) are widely known as the progenitor cells of platelets. These large, polyploid cells are a derivative of the hematopoietic stem cell (HSC), and reside in the bone marrow, lining blood vessel walls where… read more here.
Keywords: modulation megakaryopoiesis; inflammation; platelet production; platelet ... See more keywords
Effect of YAP/TAZ on megakaryocyte differentiation and platelet production
Sign Up to like & getrecommendations! Published in 2020 at "Bioscience Reports"
DOI: 10.1042/bsr20201780
Abstract: Abstract Platelet transfusion is required for life-threatening thrombocytopenic bleeding, and single donor platelet concentrate is the ideal transfusion product. However, due to the inadequate number of donors that can donate a large volume of platelets,… read more here.
Keywords: production; yap taz; platelet production; platelet ... See more keywords
Inflammatory platelet production stimulated by tyrosyl-tRNA synthetase mimicking viral infection
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2212659119
Abstract: Significance Infection is often associated with thrombocytopenia and rapid replenishment of platelets may be important to maintain vascular homeostasis. We found that an activated form of tyrosyl-tRNA synthetase (YRSACT) mimics inflammatory stress in mice, inducing… read more here.
Keywords: tyrosyl trna; viral infection; trna synthetase; infection ... See more keywords
Relationship between Hepatitis B virus infection and platelet production and dysfunction.
Sign Up to like & getrecommendations! Published in 2021 at "Platelets"
DOI: 10.1080/09537104.2021.2002836
Abstract: Hepatitis B virus (HBV) is a kind of hepatotropic DNA virus. The main target organ is liver, except for liver, HBV has been found in a variety of extrahepatic tissues, such as kidney, thyroid, pancreas,… read more here.
Keywords: infection; hbv; hepatitis virus; platelet production ... See more keywords
Megakaryocyte modification of platelets in thrombocytopenia
Sign Up to like & getrecommendations! Published in 2018 at "Current Opinion in Hematology"
DOI: 10.1097/moh.0000000000000451
Abstract: Purpose of review Platelets are small, anucleate cells that circulate within the blood and play essential roles in preserving vascular integrity. However, abnormalities in either platelet production or destruction can result in thrombocytopenia, clinically defined… read more here.
Keywords: megakaryocyte modification; modification platelets; platelets thrombocytopenia; platelet production ... See more keywords
Platelet production from induced pluripotent stem cells
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Thrombosis and Haemostasis"
DOI: 10.1111/jth.13736
Abstract: Ex vivo production of human platelets has been pursued as an alternative measure to resolve limitations in the supply and safety of current platelet transfusion products. To this end, induced pluripotent stem cells (iPSCs) are… read more here.
Keywords: production; pluripotent stem; induced pluripotent; platelet production ... See more keywords
Bifunctional effect of the inflammatory cytokine tumor necrosis factor α on megakaryopoiesis and platelet production
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Thrombosis and Haemostasis"
DOI: 10.1111/jth.15891
Abstract: Platelets are affected by many factors, such as infectious or aseptic inflammation, and different inflammatory states may induce either thrombocytopenia or thrombocytosis. Tumor necrosis factor α (TNFα) is an important inflammatory cytokine that has been… read more here.
Keywords: tumor necrosis; platelet production; necrosis factor; inflammatory cytokine ... See more keywords
A β1-tubulin-based megakaryocyte maturation reporter system identifies novel drugs that promote platelet production.
Sign Up to like & getrecommendations! Published in 2018 at "Blood advances"
DOI: 10.1182/bloodadvances.2018019547
Abstract: During maturation, megakaryocytes (MKs) express β1-tubulin (TUBB1) and rearrange their microtubule components to enlarge, form proplatelets, and eventually release platelets. The development of a platform to identify in vitro conditions that would efficiently promote MK… read more here.
Keywords: reporter; production; plp production; platelet production ... See more keywords
Murine platelet production is suppressed by S1P release in the hematopoietic niche, not facilitated by blood S1P sensing.
Sign Up to like & getrecommendations! Published in 2019 at "Blood advances"
DOI: 10.1182/bloodadvances.2019031948
Abstract: The bioactive lipid mediator sphingosine 1-phosphate (S1P) was recently assigned critical roles in platelet biology: whereas S1P1 receptor-mediated S1P gradient sensing was reported to be essential for directing proplatelet extensions from megakaryocytes (MKs) toward bone… read more here.
Keywords: platelet production; deletion; hematopoietic niche; biology ... See more keywords