Characteristics of the Thrombus Formation in Transgenic Mice with Platelet-Targeted Factor VIII Expression.
Sign Up to like & getrecommendations! Published in 2021 at "Thrombosis and haemostasis"
DOI: 10.1055/s-0041-1735531
Abstract: Platelet-targeted FVIII gene therapy can efficiently recover bleeding phenotype for hemophilia A (HA), yet characteristics of thrombus formation with this ectopic expression of factor VIII (FVIII) in platelets remain unclear. Here, we generated 2bF8trans mice… read more here.
Keywords: characteristics thrombus; 2bf8trans mice; thrombus formation; platelet targeted ... See more keywords
Platelet-targeted thrombolysis for treatment of acute ischemic stroke
Sign Up to like & getrecommendations! Published in 2022 at "Blood Advances"
DOI: 10.1182/bloodadvances.2021006691
Abstract: Key Points • Platelet-targeted thrombolysis with SCE5-scuPA achieved favorable outcomes vs tenecteplase-tPA in 2 mouse models of ischemic stroke.• Thrombolytic strategies that harness activated platelets for drug targeting better suit the platelet-rich nature of stroke-causing… read more here.
Keywords: platelet targeted; targeted thrombolysis; thrombolysis treatment; platelet ... See more keywords