Abstract 4366416: Polyvascular Disease Is Associated With Increased Platelet Activity, Hyperreactive Platelet Transcriptome and Cardiovascular Events
Sign Up to like & getrecommendations! Published in 2025 at "Circulation"
DOI: 10.1161/circ.152.suppl_3.4366416
Abstract: Background: Many patients with peripheral artery disease (PAD) have concomitant coronary artery disease (CAD). Patients with concomitant PAD and CAD, known as polyvascular disease, are a high-risk population. Platelets have potent mechanistic effects in the… read more here.
Keywords: polyvascular disease; disease; platelet transcriptome; platelet aggregation ... See more keywords
Slowed decay of mRNAs enhances platelet specific translation.
Sign Up to like & getrecommendations! Published in 2017 at "Blood"
DOI: 10.1182/blood-2016-08-736108
Abstract: Platelets are anucleate cytoplasmic fragments that lack genomic DNA, but continue to synthesize protein using a pool of messenger RNAs (mRNAs), ribosomes, and regulatory small RNAs inherited from the precursor megakaryocyte (MK). The regulatory processes… read more here.
Keywords: decay mrnas; slowed decay; translation; platelet ... See more keywords
Impact of high platelet turnover on the platelet transcriptome: Results from platelet RNA-sequencing in patients with sepsis
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DOI: 10.1371/journal.pone.0260222
Abstract: Background Sepsis is associated with high platelet turnover and elevated levels of immature platelets. Changes in the platelet transcriptome and the specific impact of immature platelets on the platelet transcriptome remain unclear. Thus, this study… read more here.
Keywords: rna sequencing; high platelet; patients sepsis; platelet ... See more keywords