Activated platelets in the tumor microenvironment for targeting of antibody-drug conjugates to tumors and metastases
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DOI: 10.7150/thno.29146
Abstract: Rationale: Platelets are increasingly recognized as mediators of tumor growth and metastasis. Hypothesizing that activated platelets in the tumor microenvironment provide a targeting epitope for tumor-directed chemotherapy, we developed an antibody-drug conjugate (ADC), comprised of… read more here.
Keywords: iiia; platelets tumor; drug; activated platelets ... See more keywords
Exchange of cellular components between platelets and tumor cells: impact on tumor cells behavior
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DOI: 10.7150/thno.64252
Abstract: Background: Platelets are active players in tumorigenesis, although the exact interactive mechanisms and their direct impact on tumor cells remain largely unknown. Methods: Bidirectional transference of lipids, proteins and RNA between platelets and tumor cells… read more here.
Keywords: platelets tumor; impact tumor; tumor cells; cells impact ... See more keywords