An Economic Perspective on Platform Trials-The Gift and the Curse.
Sign Up to like & getrecommendations! Published in 2022 at "JAMA network open"
DOI: 10.1001/jamanetworkopen.2022.21149
Abstract: Platform trials are complex innovative designs in which patients are simultaneously randomized to several experimental treatments and to a common comparator group. 1 Moreover, as the study progresses, new treatments can be added dynamically to… read more here.
Keywords: platform; platform trials; trials gift; gift curse ... See more keywords
Characteristics, Progression, and Output of Randomized Platform Trials
Sign Up to like & getrecommendations! Published in 2024 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2024.3109
Abstract: Key Points Question What are the characteristics, progression, and output of randomized platform trials? Findings In this systematic review of 127 platform trials with a total of 823 arms, primarily in the fields of oncology… read more here.
Keywords: output randomized; progression output; platform trials; randomized platform ... See more keywords
Optimization of a modeling platform to predict oncogenes from genome‐scale metabolic networks of non‐small‐cell lung cancers
Sign Up to like & getrecommendations! Published in 2021 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.13231
Abstract: Cancer cell dysregulations result in the abnormal regulation of cellular metabolic pathways. By simulating this metabolic reprogramming using constraint‐based modeling approaches, oncogenes can be predicted, and this knowledge can be used in prognosis and treatment.… read more here.
Keywords: genome scale; platform; expression; scale metabolic ... See more keywords
Coculture of Spheroids/2D Cell Layers Using a Miniaturized Patterned Platform as a Versatile Method to Produce Scaffold‐Free Tissue Engineering Building Blocks
Sign Up to like & getrecommendations! Published in 2018 at "Advanced Biosystems"
DOI: 10.1002/adbi.201700069
Abstract: A hanging drop system that allows the multiconfigurational coculture of 3D microtissues is suggested as a versatile platform to promote the formation of functional preconditioned spheroids/microtissues, namely stem‐cell‐derived tissue engineering microtissues, with potential to be… read more here.
Keywords: building blocks; scaffold free; platform; coculture ... See more keywords
A Platform to Study the Effects of Electrical Stimulation on Immune Cell Activation During Wound Healing
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DOI: 10.1002/adbi.201900106
Abstract: Wound healing is a complex process involving diverse changes in multiple cell types where the application of electric fields has been shown to accelerate wound closure. To define the efficacy of therapies based on electric… read more here.
Keywords: wound healing; study effects; electrical stimulation; platform ... See more keywords
Multi‐Scale Ice Inhibition Platform Enables Full‐Cycle Cryogenic Protection for Mouse Oocyte
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Functional Materials"
DOI: 10.1002/adfm.202402312
Abstract: Cryopreservation of metaphase II (MII) oocytes is crucial to preserve female fertility. However, the existing vitrification technology just provides partial cryogenic protection for oocytes and must use high concentrations of toxic penetrating cryoprotective agents (CPAs,… read more here.
Keywords: platform; cryogenic protection; ice; ice inhibition ... See more keywords
Liquid‐Crystal‐Powered Metasurfaces for Electrically and Thermally Switchable Photorealistic Nanoprinting and Optical Security Platform
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Functional Materials"
DOI: 10.1002/adfm.202415104
Abstract: Active or reconfigurable metasurfaces have been considered a promising paradigm for dynamic structural coloration and are starting to find their way into the ultra‐compact integrated optical display and color printing platforms. Generally, an ideal dynamic… read more here.
Keywords: liquid crystal; electrically thermally; security; thermally switchable ... See more keywords
Rational Design of Artificial Protein Platform for the Efficacy of Genetically Fused Functional Peptides
Sign Up to like & getrecommendations! Published in 2025 at "Advanced Functional Materials"
DOI: 10.1002/adfm.202515422
Abstract: Coating or tethering biofunctional peptides to material surfaces can enhance their environmental stability and activity, offering a strategy that may advance their translational potential for therapeutic and biotechnological applications. However, conventional peptide attachment approaches, such… read more here.
Keywords: artificial protein; functional peptides; protein platform; platform ... See more keywords
A Multimaterial Microphysiological Platform Enabled by Rapid Casting of Elastic Microwires.
Sign Up to like & getrecommendations! Published in 2019 at "Advanced healthcare materials"
DOI: 10.1002/adhm.201801187
Abstract: Due to escalating drug developmental costs and limitations of cardiotoxicity screening, there is an urgent need to develop robust in vitro 3D tissue culture platforms that can both facilitate the culture of human cardiac tissues… read more here.
Keywords: elastic microwires; microphysiological platform; tissue; platform ... See more keywords
An Optimally Fabricated Platform Guides Cancer‐Specific Activation of Chemotherapeutic Drugs and Toxicity‐Free Cancer Treatment
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202200765
Abstract: Cancer chemotherapeutic drugs such as doxorubicin, mitomycin C, and gemcitabine, which are mostly small synthetic molecules, are still clinically useful for cancer treatment. However, despite considerable therapeutic efficacy, severe toxicity‐associated problems, which are mainly caused… read more here.
Keywords: chemotherapeutic drugs; platform; toxicity; cancer treatment ... See more keywords
Self‐Assembled Integrative Nutrient Carrier Platform Containing Green Tea Catechin for Short Bowel Syndrome Treatment
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202201933
Abstract: Extensive resection of the small intestine leads to the development of short bowel syndrome (SBS), which reduces the effective absorptive surface area of the intestine and predisposes patients to emaciation, malnutrition, and other severe symptoms.… read more here.
Keywords: platform; short bowel; green tea; bowel syndrome ... See more keywords