An Economic Perspective on Platform Trials-The Gift and the Curse.
Sign Up to like & getrecommendations! Published in 2022 at "JAMA network open"
DOI: 10.1001/jamanetworkopen.2022.21149
Abstract: Platform trials are complex innovative designs in which patients are simultaneously randomized to several experimental treatments and to a common comparator group. 1 Moreover, as the study progresses, new treatments can be added dynamically to… read more here.
Keywords: platform; platform trials; trials gift; gift curse ... See more keywords
Optimization of a modeling platform to predict oncogenes from genome‐scale metabolic networks of non‐small‐cell lung cancers
Sign Up to like & getrecommendations! Published in 2021 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.13231
Abstract: Cancer cell dysregulations result in the abnormal regulation of cellular metabolic pathways. By simulating this metabolic reprogramming using constraint‐based modeling approaches, oncogenes can be predicted, and this knowledge can be used in prognosis and treatment.… read more here.
Keywords: genome scale; platform; expression; scale metabolic ... See more keywords
Coculture of Spheroids/2D Cell Layers Using a Miniaturized Patterned Platform as a Versatile Method to Produce Scaffold‐Free Tissue Engineering Building Blocks
Sign Up to like & getrecommendations! Published in 2018 at "Advanced Biosystems"
DOI: 10.1002/adbi.201700069
Abstract: A hanging drop system that allows the multiconfigurational coculture of 3D microtissues is suggested as a versatile platform to promote the formation of functional preconditioned spheroids/microtissues, namely stem‐cell‐derived tissue engineering microtissues, with potential to be… read more here.
Keywords: building blocks; scaffold free; platform; coculture ... See more keywords
A Platform to Study the Effects of Electrical Stimulation on Immune Cell Activation During Wound Healing
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DOI: 10.1002/adbi.201900106
Abstract: Wound healing is a complex process involving diverse changes in multiple cell types where the application of electric fields has been shown to accelerate wound closure. To define the efficacy of therapies based on electric… read more here.
Keywords: wound healing; study effects; electrical stimulation; platform ... See more keywords
A Multimaterial Microphysiological Platform Enabled by Rapid Casting of Elastic Microwires.
Sign Up to like & getrecommendations! Published in 2019 at "Advanced healthcare materials"
DOI: 10.1002/adhm.201801187
Abstract: Due to escalating drug developmental costs and limitations of cardiotoxicity screening, there is an urgent need to develop robust in vitro 3D tissue culture platforms that can both facilitate the culture of human cardiac tissues… read more here.
Keywords: elastic microwires; microphysiological platform; tissue; platform ... See more keywords
An Optimally Fabricated Platform Guides Cancer‐Specific Activation of Chemotherapeutic Drugs and Toxicity‐Free Cancer Treatment
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202200765
Abstract: Cancer chemotherapeutic drugs such as doxorubicin, mitomycin C, and gemcitabine, which are mostly small synthetic molecules, are still clinically useful for cancer treatment. However, despite considerable therapeutic efficacy, severe toxicity‐associated problems, which are mainly caused… read more here.
Keywords: chemotherapeutic drugs; platform; toxicity; cancer treatment ... See more keywords
Self‐Assembled Integrative Nutrient Carrier Platform Containing Green Tea Catechin for Short Bowel Syndrome Treatment
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202201933
Abstract: Extensive resection of the small intestine leads to the development of short bowel syndrome (SBS), which reduces the effective absorptive surface area of the intestine and predisposes patients to emaciation, malnutrition, and other severe symptoms.… read more here.
Keywords: platform; short bowel; green tea; bowel syndrome ... See more keywords
Organic Electronic Platform for Real-time Phenotypic Screening of Extracellular Vesicle-driven Breast Cancer Metastasis.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202301194
Abstract: Tumour-derived extracellular vesicles (TEVs) induce the epithelial-to-mesenchymal transition (EMT) in non-malignant cells to promote invasion and cancer metastasis, representing a novel therapeutic target in a field severely lacking in efficacious anti-metastasis treatments. However, scalable technologies… read more here.
Keywords: metastasis; platform; breast; cancer metastasis ... See more keywords
Vesicular Antibodies: A Bioactive Multifunctional Combination Platform for Targeted Therapeutic Delivery and Cancer Immunotherapy.
Sign Up to like & getrecommendations! Published in 2019 at "Advanced materials"
DOI: 10.1002/adma.201808294
Abstract: The ability to selectively kill cancerous cell populations while leaving healthy cells unaffected is a key goal in oncology. The use of nanovesicles (NVs) as chemotherapeutic delivery vehicles has been recently proven successful, yet monotherapy… read more here.
Keywords: multifunctional combination; delivery; platform; vesicular antibodies ... See more keywords
Decoupling and Reprogramming the Wiggling Motion of Midge Larvae Using a Soft Robotic Platform
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Materials"
DOI: 10.1002/adma.202109126
Abstract: The efficient motility of invertebrates helps them survive under evolutionary pressures. Reconstructing the locomotion of invertebrates and decoupling the influence of individual basic motion are crucial for understanding their underlying mechanisms, which, however, generally remain… read more here.
Keywords: locomotion; platform; reprogramming wiggling; midge ... See more keywords
Atomic‐Level Regulated 2D ReSe2: A Universal Platform Boostin Photocatalysis
Sign Up to like & getrecommendations! Published in 2023 at "Advanced Materials"
DOI: 10.1002/adma.202210164
Abstract: Solar hydrogen (H2) generation via photocatalytic water splitting is practically promising, environmentally benign, and sustainably carbon neutral. It is important therefore to understand how to controllably engineer photocatalysts at the atomic level. In this work,… read more here.
Keywords: platform; rese2; spectroscopy; atomic level ... See more keywords