A pH-responsive crosslinker platform for antibody-drug conjugate (ADC) targeting delivery.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical communications"
DOI: 10.1039/d2cc03052g
Abstract: We report a new 1-6 self-immolative, traceless crosslinker derived from the natural product gallic acid. The linker acts through a pH-dependent mechanism for drug release. This 5-(hydroxymethyl)pyrogallol orthoester derivative (HMPO) was stable for 24 hours… read more here.
Keywords: crosslinker platform; responsive crosslinker; platform antibody; drug ... See more keywords
A general platform for antibody purification utilizing engineered-micelles
Sign Up to like & getrecommendations! Published in 2019 at "mAbs"
DOI: 10.1080/19420862.2019.1565749
Abstract: ABSTRACT We introduce a new concept and potentially general platform for antibody (Ab) purification that does not rely on chromatography or specific ligands (e.g., Protein A); rather, it makes use of detergent aggregates capable of… read more here.
Keywords: platform antibody; antibody purification; engineered micelles; general platform ... See more keywords