A potential downstream platform approach for WuXiBody-based IgG-like bispecific antibodies.
Sign Up to like & getrecommendations! Published in 2020 at "Protein expression and purification"
DOI: 10.1016/j.pep.2020.105647
Abstract: WuXiBody is a novel bispecific antibody (bsAb) platform developed by WuXi Biologics. It enables almost any monoclonal antibody (mAb) sequence pair to be assembled into a bispecific construct. BsAbs based on WuXiBody can adopt either… read more here.
Keywords: platform approach; approach wuxibody; platform; wuxibody based ... See more keywords
A Macrocycle-Assisted Platform Approach to Protein Cross-Linking Via Chemically Inactive Residues.
Sign Up to like & getrecommendations! Published in 2025 at "Nano letters"
DOI: 10.1021/acs.nanolett.4c05785
Abstract: Cross-linking proteins using cross-linkers that chemically target primary amine and/or carboxyl residues has been a technically mature and robust method in protein engineering. However, depletion of chemically active residues over cross-linking presents a significant challenge… read more here.
Keywords: platform approach; cross; cross linking; protein ... See more keywords
Abstract 5896: Platform approach to develop antibodies specifically recognizing cancer-associated glycoforms
Sign Up to like & getrecommendations! Published in 2024 at "Cancer Research"
DOI: 10.1158/1538-7445.am2024-5896
Abstract: Introduction: Recent advances in antibody engineering have created a portfolio of highly potent therapeutic approaches like antibody-drug conjugates (ADCs), radioimmunoconjugates (RITs), chimeric antigen receptors (CARs) or bi-specifics. Due to the increased potency, these drugs are… read more here.
Keywords: cancer; approach develop; develop antibodies; platform approach ... See more keywords