An orthogonalized platform for genetic code expansion in both bacteria and eukaryotes.
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DOI: 10.1038/nchembio.2312
Abstract: In this study, we demonstrate the feasibility of expanding the genetic code of Escherichia coli using its own tryptophanyl-tRNA synthetase and tRNA (TrpRS-tRNATrp) pair. This was made possible by first functionally replacing this endogenous pair… read more here.
Keywords: trprs trnatrp; code expansion; platform genetic; code ... See more keywords