Development of a High-throughput NanoBRET Screening Platform to Identify Modulators of the RAS/RAF Interaction
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DOI: 10.1158/1535-7163.mct-21-0175
Abstract: Activating mutations in RAS are found in approximately 30% of human cancers, resulting in the delivery of a persistent signal to critical downstream effectors that drive tumorigenesis. RAS-driven malignancies respond poorly to conventional cancer treatments… read more here.
Keywords: screening platform; platform identify; development; ras raf ... See more keywords