An in vivo platform to select and evolve aggregation-resistant proteins
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DOI: 10.1038/s41467-020-15667-1
Abstract: Protein biopharmaceuticals are highly successful, but their utility is compromised by their propensity to aggregate during manufacture and storage. As aggregation can be triggered by non-native states, whose population is not necessarily related to thermodynamic… read more here.
Keywords: vivo platform; aggregation; platform select; aggregation resistant ... See more keywords