An Economic Perspective on Platform Trials-The Gift and the Curse.
Sign Up to like & getrecommendations! Published in 2022 at "JAMA network open"
DOI: 10.1001/jamanetworkopen.2022.21149
Abstract: Platform trials are complex innovative designs in which patients are simultaneously randomized to several experimental treatments and to a common comparator group. 1 Moreover, as the study progresses, new treatments can be added dynamically to… read more here.
Keywords: platform; platform trials; trials gift; gift curse ... See more keywords
An Overview of Platform Trials with a Checklist for Clinical Readers.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of clinical epidemiology"
DOI: 10.1016/j.jclinepi.2020.04.025
Abstract: OBJECTIVE To outline key considerations for general clinical readers when critically evaluating publications on platform trials and for researchers when designing these types of clinical trials. STUDY DESIGN AND SETTING In this review, we describe… read more here.
Keywords: trials checklist; clinical readers; platform trials; new interventions ... See more keywords
Pragmatic platform trials to improve the outcome of patients with acute kidney injury
Sign Up to like & getrecommendations! Published in 2022 at "Current Opinion in Critical Care"
DOI: 10.1097/mcc.0000000000000990
Abstract: Purpose of review There is an important need for improved diagnostic strategies and treatment among patients with acute kidney injury (AKI). Classical randomized clinical trials have generated relevant results in AKI but are associated with… read more here.
Keywords: platform; acute kidney; platform trials; kidney injury ... See more keywords
A rapid review of community engagement and informed consent processes for adaptive platform trials and alternative design trials for public health emergencies
Sign Up to like & getrecommendations! Published in 2023 at "Wellcome Open Research"
DOI: 10.12688/wellcomeopenres.19318.1
Abstract: Background: Public Health Emergencies (PHE) demand expeditious research responses to evaluate new or repurposed therapies and prevention strategies. Alternative Design Trials (ADTs) and Adaptive Platform Trials (APTs) have enabled efficient large-scale testing of biomedical interventions… read more here.
Keywords: informed consent; engagement informed; platform trials; design ... See more keywords
Adaptive, platform trials assessing therapies for hospitalized COVID-19 patients: Informed consent forms omitted a few important elements of information
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Global Health"
DOI: 10.7189/jogh.13.06019
Abstract: Background The information provided to participants of adaptive platform trials assessing therapies for COVID-19 inpatients is unknown. We aim to evaluate it by reviewing participant information sheets/informed consent forms (PIS/ICFs). Methods We searched the Cochrane… read more here.
Keywords: information; pis icfs; platform trials; elements information ... See more keywords