Chemosensitivity‐Gene Expression Correlations and Functional Enrichment Analysis Provide Insight into the Mechanism of Action of a Platinum‐Acridine Anticancer Agent
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DOI: 10.1002/cmdc.202200331
Abstract: NCI‐60 growth inhibition and gene expression profiles were analyzed using Pearson correlation and functional enrichment computational tools to demonstrate critical mechanistic differences between a nucleolus‐targeting platinum‐acridine anticancer agent (PA) and other DNA‐directed chemotherapies. The results… read more here.
Keywords: functional enrichment; agent; platinum acridine; gene expression ... See more keywords
Effect of the nonleaving groups on the cellular uptake and cytotoxicity of platinum-acridine anticancer agents
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DOI: 10.1016/j.ica.2019.04.030
Abstract: Abstract Three new derivatives of a platinum–acridine hybrid anticancer agent were synthesized using nitrile–amine coupling (amidination) chemistry. In the new structures, the nonleaving group propane-1,3-diamine (pn) of a previously optimized analogue (hybrid 1) was replaced… read more here.
Keywords: cytotoxicity; anticancer; effect nonleaving; cellular uptake ... See more keywords