Impact of antibiotic treatment during platinum chemotherapy on survival and recurrence in women with advanced epithelial ovarian cancer.
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DOI: 10.1016/j.ygyno.2020.09.010
Abstract: OBJECTIVE(S) To determine whether antibiotic treatment (ABX) during platinum chemotherapy (PC) for epithelial ovarian cancer (EOC) impacts progression-free survival (PFS) and overall survival (OS). STUDY DESIGN Retrospective single institution cohort study in women with newly… read more here.
Keywords: abx; treatment; platinum chemotherapy; antibiotic treatment ... See more keywords
Inhibition of activin signaling in lung adenocarcinoma increases the therapeutic index of platinum chemotherapy
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DOI: 10.1126/scitranslmed.aat3504
Abstract: Inhibition of activin signaling enhances the efficacy and safety of platinum chemotherapy in lung adenocarcinoma models. Blocking activin actively treats cancer Platinum-based chemotherapy is a mainstay of treatment for lung cancer, but resistance to this… read more here.
Keywords: chemotherapy; platinum; activin signaling; resistance ... See more keywords
Ganetespib in Combination with Pemetrexed–Platinum Chemotherapy in Patients with Pleural Mesothelioma (MESO-02): A Phase Ib Trial
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DOI: 10.1158/1078-0432.ccr-20-1306
Abstract: Purpose: Ganetespib, a highly potent, small-molecule Heatshock protein 90 inhibitor, has potential efficacy in malignant pleural mesothelioma (MPM) via activity on critical survival pathways and known synergies with antifolates and platinum chemotherapy. We conducted a… read more here.
Keywords: chemotherapy; pleural mesothelioma; ganetespib; phase trial ... See more keywords
Association of neuroendocrine phenotype with platinum chemotherapy outcomes in men with metastatic prostate cancer.
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DOI: 10.1200/jco.2017.35.15_suppl.e16532
Abstract: e16532Background: DNA repair defects are common in men with mCRPC, and platinum chemotherapy may have a role in selected patients. We aimed to determine whether neuroendocrine variant prostate canc... read more here.
Keywords: prostate; platinum; association neuroendocrine; neuroendocrine phenotype ... See more keywords