Chronic effects of platinum(IV) complex and its diamine ligand on rat heart function: comparison with cisplatin
Sign Up to like & getrecommendations! Published in 2019 at "Molecular and Cellular Biochemistry"
DOI: 10.1007/s11010-019-03533-8
Abstract: The aim of the present study was to compare the cardiodynamic parameters in the isolated rat heart in animals chronically treated with cisplatin, platinum(IV) complex and its diamine ligand. Sixty Wistar albino rats (8 weeks old)… read more here.
Keywords: platinum; heart; rat heart; function ... See more keywords
Synthesis and UV-light induced oligomerization of a benzofulvene-based neutral platinum(II) complex
Sign Up to like & getrecommendations! Published in 2021 at "European Polymer Journal"
DOI: 10.1016/j.eurpolymj.2021.110597
Abstract: Abstract Neutral platinum(II) complex 2-PTPC-BF3a was easily prepared from benzofulvene derivative 2-Pyr-BF3a in order to evaluate the effects in the aggregation/polymerization behavior of a bulky substituent capable of establishing intermolecular metal–metal interactions in the close… read more here.
Keywords: ptpc bf3a; platinum; neutral platinum; platinum complex ... See more keywords
The influence of the ethane-1,2-diamine ligand on the activity of a monofunctional platinum complex.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of inorganic biochemistry"
DOI: 10.1016/j.jinorgbio.2017.07.029
Abstract: The continued use of platinum-based chemotherapeutic drugs in the clinic mandates the need for further investigation of the biological activity of structural analogues of the clinically approved complexes. Of interest are monofunctional platinum(II) complexes, which… read more here.
Keywords: platinum; monofunctional platinum; ethane diamine; ligand ... See more keywords
Cyclometalation and pentafluorophenyl transfer in protonolysis of a chelating Bis-NHC Platinum(II) complex
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Organometallic Chemistry"
DOI: 10.1016/j.jorganchem.2018.08.023
Abstract: Abstract The reactions of the bis-NHC platinum complex cis-[PtMe2(bis NHC 1)], 1, in which bis NHC 1 = 1,1′-methylene-3,3′-bis[(N-(tert-butyl)imidazole-2-ylidene], with strong acids and thermolysis of the reaction products were investigated. The reaction of 1 with 1 equiv… read more here.
Keywords: platinum; bis nhc; c6f5; nhc platinum ... See more keywords
A novel platinum complex containing a piplartine derivative exhibits enhanced cytotoxicity, causes oxidative stress and triggers apoptotic cell death by ERK/p38 pathway in human acute promyelocytic leukemia HL-60 cells
Sign Up to like & getrecommendations! Published in 2019 at "Redox Biology"
DOI: 10.1016/j.redox.2018.10.006
Abstract: Piplartine (piperlongumine) is a plant-derived compound found in some Piper species that became a novel potential antineoplastic agent. In the present study, we synthesized a novel platinum complex containing a piplartine derivative cis-[PtCl(PIP-OH)(PPh3)2]PF6 (where, PIP-OH… read more here.
Keywords: piplartine; cell; platinum complex; cytotoxicity ... See more keywords
Construction of disulfide bonds in peptides via immobilized platinum(IV) complex oxidation
Sign Up to like & getrecommendations! Published in 2020 at "Tetrahedron Letters"
DOI: 10.1016/j.tetlet.2019.151496
Abstract: Abstract A novel TentaGel resin supported platinum(IV) complex named TentaGel-Pt(IV) was synthesized and characterized by SEM, XPS, ICP-MS and UV–vis spectrophotometry. The formation of intramolecular disulfides in eleven dithiol-containing peptides of variable lengths using TentaGel-Pt(IV)… read more here.
Keywords: construction disulfide; peptides via; platinum complex; oxidation ... See more keywords
Change in Luminescence Induced by Solution-Mediated Phase-Transition of Cyclometalated Platinum(II) Complex with Isoquinoline Carboxylate.
Sign Up to like & getrecommendations! Published in 2017 at "Inorganic chemistry"
DOI: 10.1021/acs.inorgchem.7b01466
Abstract: Changes in luminescence due to solution-mediated phase transition (SMPT) and crystal-to-crystal phase transitions of a novel cyclometalated platinum(II) complex with isoquinoline-1-carboxylate (Iq-1-COO-) [Pt(bzq)(Iq-1-COO)] (bzq-: benzoquinolinate) were studied experimentally and theoretically. Recrystallization of the complex allowed… read more here.
Keywords: phase transition; mediated phase; solution; cyclometalated platinum ... See more keywords
A Borane Platinum Complex Undergoing Reversible Hydride Migration in Solution.
Sign Up to like & getrecommendations! Published in 2018 at "Inorganic chemistry"
DOI: 10.1021/acs.inorgchem.7b02807
Abstract: Reaction of [Pt(κ2-C,N-ppy)(dmso)Cl], 1 (Hppy = 2-phenylpyridine), with Na[H2B(mb)2] (Hmb = 2-mercapto-benzimidazole) smoothly afforded the complex {[(κ3-S,B,S-HB(mb)2]Pt(κ2-C,N-ppy)H}, 2, featuring a strong reverse-dative Pt → B σ interaction in the solid state. When dissolved in thf… read more here.
Keywords: borane platinum; complex undergoing; solution; platinum complex ... See more keywords
Enhancing Cytotoxicity of a Monofunctional Platinum Complex via a Dual-DNA-Damage Approach.
Sign Up to like & getrecommendations! Published in 2019 at "Inorganic chemistry"
DOI: 10.1021/acs.inorgchem.9b02033
Abstract: Mitochondrial DNA (mtDNA) is an attractive cellular target for anticancer agents in addition to nuclear DNA (nDNA). The cationic platinum(II) complex cis-[Pt(NP)(NH3)2Cl]NO3 (PtNP, NP = N-(2-ethylpyridine)-1,8-naphthalimide) bearing the DNA-intercalating moiety NP was designed. The structure… read more here.
Keywords: dna damage; platinum complex; ptnp; dna ... See more keywords
Reversible stimuli-responsive chromism of a cyclometallated platinum(II) complex.
Sign Up to like & getrecommendations! Published in 2020 at "Chemical communications"
DOI: 10.1039/d0cc06775j
Abstract: We report the reversible chromism and luminescence of a cyclometalated platinum(ii) complex that forms dimers, with close PtPt interactions that can be modulated by solvent and temperature. The precise reversible control may be exploited in… read more here.
Keywords: chromism; reversible stimuli; stimuli responsive; platinum complex ... See more keywords
Immunogenicity and cytotoxicity of a platinum(IV) complex derived from capsaicin.
Sign Up to like & getrecommendations! Published in 2021 at "Dalton transactions"
DOI: 10.1039/d0dt03470c
Abstract: Platinum-based anticancer drugs constitute the cornerstone of chemotherapy for various cancers. Although cytotoxic agents are considered to have immunosuppressive effects, increasing evidence suggests that some cytotoxic compounds can effectively stimulate the antitumor immune response by… read more here.
Keywords: platinum; cancer cells; panc; cytotoxicity ... See more keywords