Value of skin tests for managing allergic hypersensitivity reactions to platinum compounds
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Clinical Pharmacy"
DOI: 10.1007/s11096-021-01271-w
Abstract: Background Platinum-based therapy continues to be one of the pillars of the treatment of different types of cancer. However, many times the responsible clinician renounces its use after the appearance of a hypersensitivity reaction. Objective… read more here.
Keywords: skin tests; platinum; hypersensitivity reactions; platinum compounds ... See more keywords
Cyclometallated platinum(IV) compounds as promising antitumour agents
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Organometallic Chemistry"
DOI: 10.1016/j.jorganchem.2018.10.008
Abstract: abstract Since the discovery of the anticancer activity of cisplatin by Rosenberg, extensive research has been carried out in order to develop new and more efficient platinum-containing drugs. In recent years, platinum(IV) compounds are appealing… read more here.
Keywords: antitumour agents; platinum compounds; promising antitumour; compounds promising ... See more keywords
Quantification of cytostatic platinum compounds in wastewater by inductively coupled plasma mass spectrometry after ion exchange extraction
Sign Up to like & getrecommendations! Published in 2020 at "Microchemical Journal"
DOI: 10.1016/j.microc.2020.104862
Abstract: Abstract Cytostatic platinum compounds (CPCs) are pharmaceutical compounds widely used in chemotherapy. However, these compounds have important side effects and can be toxic to the biota once they are excreted by patients and reach the… read more here.
Keywords: extraction; determination; determination cpcs; platinum compounds ... See more keywords
Dicarboxylate Modulating Molecular-Ionic Platinum Compounds with Variable Stacking and Photoluminescence.
Sign Up to like & getrecommendations! Published in 2022 at "Inorganic chemistry"
DOI: 10.1021/acs.inorgchem.1c03146
Abstract: Under solvothermal conditions, 10 molecular-ionic platinum compounds [Pt(NIA)2]·(L)·nH2O (L = dicarboxylate) were synthesized. In the reaction, acetonitrile undergoes trimerization in situ to generate N-(1-iminoethyl)acetamidine (NIA), which coordinates to PtII ions in forming the N-(1-iminoethyl)acetamidine platinum… read more here.
Keywords: photoluminescence; molecular ionic; dicarboxylate; ionic platinum ... See more keywords
Nanocarriers containing platinum compounds for combination chemotherapy
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.1050928
Abstract: Platinum compounds-based drugs are used widely in the clinic for the treatment of many types of cancer. However, serious undesirable side effects and intrinsic or acquired resistance limit their successful clinic use. Nanocarrier-based combination chemotherapy… read more here.
Keywords: platinum; nanocarriers containing; platinum compounds; combination chemotherapy ... See more keywords
Early and Long-Term Ototoxicity Noted in Children Due to Platinum Compounds: Prevalence and Risk Factors
Sign Up to like & getrecommendations! Published in 2023 at "Biomedicines"
DOI: 10.3390/biomedicines11020261
Abstract: Background: Platinum compounds are a group of fundamental chemotherapeutics used in the treatment of solid tumors, but they are burdened by side effects, such as ototoxicity. The objective of this study was to evaluate the… read more here.
Keywords: risk factors; ototoxicity; platinum compounds; treatment ... See more keywords
Gender and Sex-Related Differences in Normal Tissue Effects Induced by Platinum Compounds
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceuticals"
DOI: 10.3390/ph15020255
Abstract: Gender medicine in the field of oncology is an under-researched area, despite the existing evidence towards gender-dependent response to therapy and treatment-induced adverse effects. Oncological treatment aims to fulfil its main goal of achieving high… read more here.
Keywords: induced platinum; normal tissue; sex; effects induced ... See more keywords
DNA Conformational Changes Induced by Its Interaction with Binuclear Platinum Complexes in Solution Indicate the Molecular Mechanism of Platinum Binding
Sign Up to like & getrecommendations! Published in 2022 at "Polymers"
DOI: 10.3390/polym14102044
Abstract: Platinum anticancer drugs inhibit the division of cancer cells through a DNA binding mechanism. The bimetallic platinum compounds have a possibility for blocking DNA replication via the cross-linking of DNA functional groups at different distances.… read more here.
Keywords: microscopy; conformational changes; mechanism; platinum ... See more keywords