Platinum Drug-Incorporating Polymeric Nanosystems for Precise Cancer Therapy.
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DOI: 10.1002/smll.202208241
Abstract: Platinum (Pt) drugs are widely used in clinic for cancer therapy, but their therapeutic outcomes are significantly compromised by severe side effects and acquired drug resistance. With the emerging immunotherapy and imaging-guided cancer therapy, precise… read more here.
Keywords: platinum drug; therapy; polymeric nanosystems; cancer therapy ... See more keywords
Combining the platinum(ii) drug candidate kiteplatin with 1,10-phenanthroline analogues.
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DOI: 10.1039/c7dt04108j
Abstract: Platinum complexes of the type [Pt(PL)(AL)]2+ where PL is a derivative of 1,10-phenanthroline and AL is cis-1,4-diaminocyclohexane (1,4-dach), have been synthesised and characterised by ultraviolet spectroscopy, elemental microanalysis, nuclear magnetic resonance and X-ray crystallography. The… read more here.
Keywords: candidate kiteplatin; kiteplatin phenanthroline; drug candidate; phenanthroline ... See more keywords
Addressing the gaps in homeostatic mechanisms of copper and copper dithiocarbamate complexes in cancer therapy: a shift from classical platinum-drug mechanisms.
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DOI: 10.1039/d3dt00366c
Abstract: The platinum drug, cisplatin, is considered as among the most successful medications in cancer treatment. However, due to its inherent toxicity and resistance limitations, research into other metal-based non-platinum anticancer medications with diverse mechanisms of… read more here.
Keywords: platinum drug; copper copper; copper; cancer ... See more keywords
2-Hydroxyestradiol Overcomes Mesenchymal Stem Cells-Mediated Platinum Chemoresistance in Ovarian Cancer Cells in an ERK-Independent Fashion
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DOI: 10.3390/molecules27030804
Abstract: Ovarian cancer (OC) is the second most common type of gynecological malignancy. Platinum (Pt)-based chemotherapy is the standard of care for OC, but toxicity and acquired chemoresistance has proven challenging. Recently, we reported that sensitivity… read more here.
Keywords: platinum drug; mediated platinum; ovarian cancer; platinum ... See more keywords