Recent advances of platinum-based anticancer complexes in combinational multimodal therapy.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202300253
Abstract: Platinum drugs with manifest therapeutic effects are widely used, but their systemic toxicity and the drug resistance acquired by cancer cells limit their clinical applications. Thus, the exploration on appropriate methods and strategies to overcome… read more here.
Keywords: anticancer complexes; based anticancer; therapy; platinum drugs ... See more keywords
Blood Components as Carriers for Small‐Molecule Platinum Anticancer Drugs
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DOI: 10.1002/cmdc.202200482
Abstract: The efficacy of platinum drugs is limited by severe side effects, drug resistance, and poor pharmacokinetic properties. Utilizing long‐lasting blood components as drug carriers is a promising strategy to improve the circulation half‐lives and tumor… read more here.
Keywords: small molecule; platinum drugs; blood components; molecule platinum ... See more keywords
DNA modification by cisplatin-like Pt(II) complexes containing 1,1′-binaphtyl-2,2′-diamine ligand does not correlate with their antiproliferative activity in cancer cells
Sign Up to like & getrecommendations! Published in 2019 at "Inorganica Chimica Acta"
DOI: 10.1016/j.ica.2019.06.003
Abstract: Abstract DNA-reactive platinum complexes, such as cisplatin and its antitumor derivatives, are presupposed to kill actively proliferating cancer cells. Thus, the intense research of the mechanism of action (MoA) of this class of platinum drugs… read more here.
Keywords: cancer cells; dna binding; platinum drugs; cancer ... See more keywords
Drug induced self-assembly of triblock copolymers into polymersomes for the synergistic dual-drug delivery of platinum drugs and paclitaxel
Sign Up to like & getrecommendations! Published in 2017 at "Polymer Chemistry"
DOI: 10.1039/c7py01162h
Abstract: Co-delivery of two drugs in one nanoparticle is increasingly used to overcome, for example, multi-drug resistance in cancer therapy and therefore suitable drug carriers need to be developed. In this work, a well-known polymer based… read more here.
Keywords: platinum; self assembly; platinum drugs; delivery ... See more keywords
A chemical perspective on the clinical use of platinum-based anticancer drugs.
Sign Up to like & getrecommendations! Published in 2022 at "Dalton transactions"
DOI: 10.1039/d2dt01875f
Abstract: Platinum drugs have been a mainstay of cancer chemotherapy since the introduction of cisplatin in the 1970s. Since then, carboplatin and oxaliplatin have been approved world-wide and nedaplatin, lobaplatin, heptaplatin, dicycloplatin, and miriplatin have been… read more here.
Keywords: platinum based; chemical perspective; platinum drugs; platinum ... See more keywords
Platinum-drugs Ototoxicity in Pediatric Patients With Brain Tumors: A 10-Year Review
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Pediatric Hematology/Oncology"
DOI: 10.1097/mph.0000000000001637
Abstract: Purpose: Platinum-derived chemotherapy is one of the cornerstones in the treatment of central nervous system tumors in children. We aimed to assess the incidence of hearing loss in children after the exposure to platinum drugs.… read more here.
Keywords: drugs ototoxicity; platinum drugs; brain tumors; ototoxicity ... See more keywords
Targeting critical pathways in ferroptosis and enhancing antitumor therapy of Platinum drugs for colorectal cancer
Sign Up to like & getrecommendations! Published in 2023 at "Science Progress"
DOI: 10.1177/00368504221147173
Abstract: Colorectal cancer (CRC) can be resistant to platinum drugs, possibly through ferroptosis suppression, albeit the need for further work to completely understand this mechanism. This work aimed to sum up current findings pertaining to oxaliplatin… read more here.
Keywords: platinum drugs; crc; ferroptosis; colorectal cancer ... See more keywords
Nanoparticles Loaded with Platinum Drugs for Colorectal Cancer Therapy
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms231911261
Abstract: Colorectal cancer is a common cancer in both men and women. Numerous studies on the therapeutic effectiveness of nanoparticles against colorectal cancer have been reported. Platinum treatments as well as other medications comprising of nanoparticles… read more here.
Keywords: loaded platinum; colorectal cancer; nanoparticles loaded; platinum drugs ... See more keywords