Phase I study of combined indomethacin and platinum-based chemotherapy to reduce platinum-induced fatty acids
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Chemotherapy and Pharmacology"
DOI: 10.1007/s00280-018-3563-2
Abstract: PurposeChemotherapy-resistance remains a major obstacle to effective anti-cancer treatment. We previously showed that platinum analogs cause the release of two fatty acids. These platinum-induced fatty acids (PIFAs) induced complete chemoresistance in mice, whereas co-administration of… read more here.
Keywords: chemotherapy; phase; platinum; induced fatty ... See more keywords
The melanocortin signaling cAMP axis accelerates repair and reduces mutagenesis of platinum-induced DNA damage
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DOI: 10.1038/s41598-017-12056-5
Abstract: Using primary melanocytes and HEK293 cells, we found that cAMP signaling accelerates repair of bi- and mono-functional platinum-induced DNA damage. Elevating cAMP signaling either by the agonistic MC1R ligand melanocyte stimulating hormone (MSH) or by… read more here.
Keywords: dna damage; platinum; camp; induced dna ... See more keywords
Effect of renin-angiotensin system inhibitors on pemetrexed plus platinum-induced hematological toxicities: a multicenter retrospective study using three propensity score analyses.
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DOI: 10.1691/ph.2021.1409
Abstract: Hematological toxicities induced by pemetrexed plus platinum therapy remain a critical issue in clinical practice. We hypothesized that inhibition of the renin-angiotensin system (RAS) can ameliorate pemetrexed-induced hematological toxicities through drug-drug interactions involving organic anion… read more here.
Keywords: hematological toxicities; renin angiotensin; plus platinum; pemetrexed plus ... See more keywords
Application Potential of Plant-Derived Medicines in Prevention and Treatment of Platinum-Induced Peripheral Neurotoxicity
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DOI: 10.3389/fphar.2021.792331
Abstract: As observed with other chemotherapeutic agents, the clinical application of platinum agents is a double-edged sword. Platinum-induced peripheral neuropathy (PIPN) is a common adverse event that negatively affects clinical outcomes and patients’ quality of life.… read more here.
Keywords: derived medicines; platinum induced; plant derived; plant ... See more keywords
Genome-wide analyses of platinum-induced ototoxicity in childhood cancer patients: Results of GO-CAT and United Kingdom MAGIC consortia
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.980309
Abstract: Hearing loss (ototoxicity) is a major adverse effect of cisplatin and carboplatin chemotherapy. The aim of this study is to identify novel genetic variants that play a role in platinum-induced ototoxicity. Therefore, a genome-wide association… read more here.
Keywords: united kingdom; genome wide; ototoxicity; platinum induced ... See more keywords