Delivery of Platinum (IV) Prodrugs via Bi2Te3 Nanoparticles for Photothermal-Chemotherapy and Photothermal/Photoacoustic Imaging.
Sign Up to like & getrecommendations! Published in 2020 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.0c00458
Abstract: Combinational administration of photothermal therapy (PTT) and chemotherapy (CT) shows great potential in improving the efficiency of tumor treatment. Herein, we designed a novel nanocomposite Pt@Bi2Te3 composed of bismuth telluride (Bi2Te3) nanoparticles and platinum (IV)… read more here.
Keywords: platinum prodrugs; photoacoustic imaging; bi2te3; therapy ... See more keywords
A platinum-based fluorescent "turn on" sensor to decipher the reduction of platinum(IV) prodrugs.
Sign Up to like & getrecommendations! Published in 2022 at "Dalton transactions"
DOI: 10.1039/d2dt00124a
Abstract: We report a strategy to use a fluorescence "turn on" sensor to quantify the reduction of platinum(IV) prodrugs in a real-time mode by simply and conveniently monitoring the fluorescence intensity. Proteins with high molecular weights,… read more here.
Keywords: reduction; reduction platinum; turn sensor; platinum prodrugs ... See more keywords
In-situ oxidative polymerization of platinum(IV) prodrugs in pore-confined spaces of CaCO3 nanoparticles for cancer chemoimmunotherapy
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DOI: 10.1039/d3sc02264a
Abstract: Drug resistance and metastases are the leading causes of death inside clinics. To overcome this limitation, there is an urgent need for new therapeutic agents and drug formulations that are... read more here.
Keywords: platinum prodrugs; oxidative polymerization; prodrugs pore; situ oxidative ... See more keywords
Cyclooxygenase-Inhibiting Platinum(IV) Prodrugs with Potent Anticancer Activity
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DOI: 10.3390/pharmaceutics14040787
Abstract: Platinum(IV) prodrugs of the [Pt(PL)(AL)(COXi)(OH)]2+ type scaffold (where PL is 1,10-phenanthroline or 5,6-dimethyl-1,10-phenanthroline, AL is 1S,2S-diaminocyclohexane, and COXi is a COX inhibitor, either indomethacin or aspirin) were synthesised and characterised, and their biological activity was… read more here.
Keywords: cyclooxygenase inhibiting; inhibiting platinum; platinum prodrugs; activity ... See more keywords
Potent Platinum(IV) Prodrugs That Incorporate a Biotin Moiety to Selectively Target Cancer Cells
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DOI: 10.3390/pharmaceutics14122780
Abstract: Four platinum(IV) prodrugs incorporating a biotin moiety to selectively target cancer cells were synthesised, characterised, and their biological activity assessed. All complexes exhibited exceptional in vitro cytotoxicity against a panel of cancer cell lines, with… read more here.
Keywords: cancer; platinum prodrugs; biotin moiety; platinum ... See more keywords