Platinum(II) and Ruthenium(II) complexes in medicine: Antimycobacterial and Anti-HIV activities
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DOI: 10.1016/j.ccr.2020.213285
Abstract: Abstract Approximately 100 million people worldwide are affected by M. Tuberculosis (Mtb), a contagious disease which causes death in humans and is considered to be quite deadly throughout the world (about 1.5 million deaths annually).… read more here.
Keywords: medicine; platinum ruthenium; antimycobacterial anti; anti hiv ... See more keywords
Niacin-ligated platinum(iv)-ruthenium(ii) chimeric complexes synergistically suppress tumor metastasis and growth with potentially reduced toxicity in vivo.
Sign Up to like & getrecommendations! Published in 2020 at "Chemical communications"
DOI: 10.1039/c9cc09016a
Abstract: Niacin-ligated platinum(iv)-ruthenium(ii) chimeric complexes (PtRu 1-4) have been synthesized and evaluated for their antitumor performance. Using the optimal complex, PtRu-1, we show that this water-soluble chimeric prodrug not only potently inhibits the metastasis and proliferation… read more here.
Keywords: ruthenium chimeric; platinum ruthenium; niacin ligated; ligated platinum ... See more keywords