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Platinum salts in the treatment of BRCA-associated breast cancer: A true targeted chemotherapy?

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1 Published in 2019 at "Critical reviews in oncology/hematology"

DOI: 10.1016/j.critrevonc.2019.01.016

Abstract: Germline pathogenic mutations in breast cancer (BC) susceptibility genes (gBRCA1/2) are the most frequent inherited alterations in BC and are involved in the homologous recombination pathway, the principal mechanism of DNA double strand break repair.… read more here.

Keywords: platinum; platinum salts; breast cancer; brca ... See more keywords