ERCC1-XPF deficiency is a predictor of olaparib induced synthetic lethality and platinum sensitivity in epithelial ovarian cancers.
Sign Up to like & getrecommendations! Published in 2019 at "Gynecologic oncology"
DOI: 10.1016/j.ygyno.2019.02.014
Abstract: PURPOSE PARP inhibitor maintenance therapy in platinum sensitive sporadic ovarian cancers improves progression free survival. However, biomarker for synthetic lethality in platinum sensitive sporadic disease is yet to be defined. ERCC1-XPF heterodimer is a key… read more here.
Keywords: platinum sensitivity; platinum; ercc1 xpf; ovarian cancers ... See more keywords
WT1 expression associated with platinum-sensitivity and improved progression-free survival in uterine serous carcinoma
Sign Up to like & getrecommendations! Published in 2021 at "Gynecologic Oncology"
DOI: 10.1016/s0090-8258(21)01290-7
Abstract: Objectives: Wilms tumor gene 1 (WT1) expression is a hallmark of ovarian serous carcinoma (OSC) and considered to be diagnostic marker of these tumors, differentiating them from uterine serous carcinoma (USC), traditionally thought to rarely… read more here.
Keywords: platinum sensitivity; wt1; serous carcinoma; expression ... See more keywords
Platinum sensitivity in metastatic prostate cancer: does histology matter?
Sign Up to like & getrecommendations! Published in 2017 at "Prostate Cancer and Prostatic Diseases"
DOI: 10.1038/s41391-017-0017-6
Abstract: BackgroundPlatinum-based chemotherapy is effective in men with neuroendocrine prostate cancer (NEPC), but it is unclear whether histology (adenocarcinoma vs. non-adenocarcinoma NEPC variants) is predictive of platinum sensitivity. Given that NEPC exists as a spectrum, there… read more here.
Keywords: prostate; platinum sensitivity; prostate cancer; histology ... See more keywords
Evaluation of factors associated with platinum-sensitivity status and survival in limited-stage small cell lung cancer patients treated with chemoradiotherapy.
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.19073
Abstract: In this retrospective study, we analyzed the association of clinicopathological factors and therapeutic plans with platinum-sensitivity status and survival of limited-stage small cell lung cancer (LS-SCLC) patients. We enrolled 452 LS-SCLC patients with 279 platinum… read more here.
Keywords: sensitivity status; platinum sensitivity; status survival; survival limited ... See more keywords
Deep learning magnetic resonance imaging predicts platinum sensitivity in patients with epithelial ovarian cancer
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.895177
Abstract: Objective The aim of the study is to develop and validate a deep learning model to predict the platinum sensitivity of patients with epithelial ovarian cancer (EOC) based on contrast-enhanced magnetic resonance imaging (MRI). Methods… read more here.
Keywords: sensitivity; patients epithelial; validation; sensitivity patients ... See more keywords
Development of Machine Learning Models to Predict Platinum Sensitivity of High-Grade Serous Ovarian Carcinoma
Sign Up to like & getrecommendations! Published in 2021 at "Cancers"
DOI: 10.3390/cancers13081875
Abstract: Simple Summary High-grade serous ovarian carcinoma (HGSOC) is the most aggressive histologic type of epithelial ovarian cancer, associated with high recurrence and mortality rates despite standard treatment. In accordance with the era of precision cancer… read more here.
Keywords: machine; platinum sensitivity; machine learning; high grade ... See more keywords