Improvement of pneumonia by curcumin-loaded bionanosystems based on platycodon grandiflorum polysaccharides via calming cytokine storm.
Sign Up to like & getrecommendations! Published in 2022 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2022.01.194
Abstract: Pneumonia can lead to high morbidity and mortality secondary to uncontrolled inflammation of the lung tissue. Blocking cytokine storm storms may be the key to saving the life of patients with severe pneumonia. According to… read more here.
Keywords: lung; cytokine storm; grandiflorum polysaccharides; storm ... See more keywords
Freeze-thaw and ultrasound pretreatment before microwave combined drying affects drying kinetics, cell structure and quality parameters of Platycodon grandiflorum
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DOI: 10.1016/j.indcrop.2021.113391
Abstract: Abstract Platycodon grandiflorum (Jacq. A.DC.) is a kind of plant with high medical application value, and drying is an effective method to preserve its medical and commercial values. In this study, effects of freeze-thaw and… read more here.
Keywords: pretreatment; freeze thaw; thaw ultrasound; platycodon grandiflorum ... See more keywords
Simultaneous determination of various platycosides in Four Platycodon grandiflorum cultivars by UPLC-QTOF/MS
Sign Up to like & getrecommendations! Published in 2019 at "Applied Biological Chemistry"
DOI: 10.1186/s13765-019-0457-x
Abstract: In Platycodi Radix (root of Platycodon grandiflorum), there are a number of platycosides that consist of a pentacyclic triterpenoid aglycone and two sugar moieties. Due to the pharmacological activities of platycosides, it is critical to… read more here.
Keywords: platycosides four; uplc qtof; platycodi radix; various platycosides ... See more keywords
Chromosome-Scale Genome Assembly and Triterpenoid Saponin Biosynthesis in Korean Bellflower (Platycodon grandiflorum)
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24076534
Abstract: Platycodon grandiflorum belongs to the Campanulaceae family and is an important medicinal and food plant in East Asia. However, on the whole, the genome evolution of P. grandiflorum and the molecular basis of its major… read more here.
Keywords: genome assembly; platycodon grandiflorum; grandiflorum; scale genome ... See more keywords
The Effect of Different Water Extracts from Platycodon grandiflorum on Selected Factors Associated with Pathogenesis of Chronic Bronchitis in Rats
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DOI: 10.3390/molecules25215020
Abstract: The aim of this study was to assess the activity of extracts from Platycodon grandiflorum A. DC (PG) in a model of chronic bronchitis in rats. The research was carried out on three water extracts:… read more here.
Keywords: bronchitis; extracts platycodon; bronchitis rats; chronic bronchitis ... See more keywords
Phenolic Constituents from Platycodon grandiflorum Root and Their Anti-Inflammatory Activity
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DOI: 10.3390/molecules26154530
Abstract: Six lignols (1–6), including two new compounds (+)-(7R,8R)-palmitoyl alatusol D (1) and (+)-(7R,8R)-linoleyl alatusol D (2), along with four phenolics (7–10), a neolignan (11), three alkyl aryl ether-type lignans (12–14), two furofuran-type lignans (15–16), three… read more here.
Keywords: anti inflammatory; phenolic constituents; root; inflammatory activity ... See more keywords
A Novel Drug with Potential to Treat Hyperbilirubinemia and Prevent Liver Damage Induced by Hyperbilirubinemia: Carbon Dots Derived from Platycodon grandiflorum
Sign Up to like & getrecommendations! Published in 2023 at "Molecules"
DOI: 10.3390/molecules28062720
Abstract: Platycodon grandiflorum (PG) is a traditional Chinese medicine with a long history, but its active compounds have not been reported. In this study, novel carbon dots (CDs), PG-based CDs (PGC-CDs), were discovered and prepared from… read more here.
Keywords: induced hyperbilirubinemia; damage; pgc cds; microscopy ... See more keywords
Platycodon grandiflorum Saponins Ameliorate Cisplatin-Induced Acute Nephrotoxicity through the NF-κB-Mediated Inflammation and PI3K/Akt/Apoptosis Signaling Pathways
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DOI: 10.3390/nu10091328
Abstract: Although cisplatin is a potent chemotherapeutic agent against cancers, its clinical application is seriously limited by its severe side effects of nephrotoxicity. Previous studies reported that saponins isolated from the roots of Platycodon grandiflorum (PGS)… read more here.
Keywords: cisplatin; pgs; pi3k akt; cisplatin induced ... See more keywords
Immunostimulatory activity of hydrolyzed and fermented Platycodon grandiflorum extract occurs via the MAPK and NF-κB signaling pathway in RAW 264.7 cells
Sign Up to like & getrecommendations! Published in 2022 at "Nutrition Research and Practice"
DOI: 10.4162/nrp.2022.16.6.685
Abstract: BACKGROUND/OBJECTIVES Platycodon grandiflorum (PG) has long been known as a medicinal herb effective in various diseases, including bronchitis and asthma, but is still more widely used for food. Fermentation methods are being applied to increase… read more here.
Keywords: hydrolyzed fermented; 264 cells; platycodon grandiflorum; raw 264 ... See more keywords
Immune-enhancing effect of hydrolyzed and fermented Platycodon grandiflorum extract in cyclophosphamide-induced immunosuppressed BALB/c mice
Sign Up to like & getrecommendations! Published in 2022 at "Nutrition Research and Practice"
DOI: 10.4162/nrp.2023.17.2.206
Abstract: BACKGROUND/OBJECTIVES The immunomodulatory effect of Platycodon grandiflorum (PG) has been reported, but studies on its mechanism are still lacking. This study was undertaken to confirm whether the hydrolyzed and fermented PG extract (HFPGE) obtained by… read more here.
Keywords: hydrolyzed fermented; effect; platycodon grandiflorum; group ... See more keywords