No Effect of Plazomicin on the Pharmacokinetics of Metformin in Healthy Subjects
Sign Up to like & getrecommendations! Published in 2019 at "Clinical Pharmacology in Drug Development"
DOI: 10.1002/cpdd.648
Abstract: Plazomicin is an aminoglycoside that was engineered to overcome aminoglycoside‐modifying enzymes, which are the most common aminoglycoside resistance mechanism in Enterobacteriaceae. Because plazomicin is predominantly eliminated via renal pathways, an in vitro study was conducted… read more here.
Keywords: plasma concentration; metformin; time; healthy subjects ... See more keywords
A Phase 1 Study of Intravenous Plazomicin in Healthy Adults to Assess Potential Effects on the QT/QTc Interval, Safety, and Pharmacokinetics
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DOI: 10.1002/cpdd.653
Abstract: Plazomicin is an aminoglycoside with in vitro activity against multidrug‐resistant Enterobacteriaceae. A phase 1, randomized, double‐blind, crossover study assessed the potential effects of plazomicin on cardiac repolarization (NCT01514929). Fifty‐six healthy adults (24 men, 32 women)… read more here.
Keywords: phase; healthy adults; qtc interval; effect ... See more keywords
Evaluation of Plazomicin, Tigecycline, and Meropenem Pharmacodynamic Exposure against Carbapenem-Resistant Enterobacteriaceae in Patients with Bloodstream Infection or Hospital-Acquired/Ventilator-Associated Pneumonia from the CARE Study (ACHN-490-007)
Sign Up to like & getrecommendations! Published in 2019 at "Infectious Diseases and Therapy"
DOI: 10.1007/s40121-019-0251-4
Abstract: IntroductionCARE was a Phase 3, randomized study evaluating the efficacy and safety of plazomicin-based combination therapy compared with colistin-based combination therapy for the treatment of patients with bloodstream infections or hospital-acquired/ventilator-associated pneumonia due to carbapenem-resistant… read more here.
Keywords: patients bloodstream; tigecycline meropenem; exposure; meropenem ... See more keywords
Plazomicin: an intravenous aminoglycoside antibacterial for the treatment of complicated urinary tract infections
Sign Up to like & getrecommendations! Published in 2020 at "Expert Review of Anti-infective Therapy"
DOI: 10.1080/14787210.2020.1759419
Abstract: ABSTRACT Introduction Antimicrobial resistance continues to be a major public health concern due to the emergence and spread of multi-drug resistant (MDR) organisms, including extended spectrum ß-lactamase (ESBL) and carbapenemase producing Enterobacterales. Plazomicin is a… read more here.
Keywords: urinary tract; complicated urinary; tract infections; plazomicin ... See more keywords
1400. Mass Balance, Metabolism, and Excretion of [14C]-Plazomicin in Healthy Human Subjects
Sign Up to like & getrecommendations! Published in 2018 at "Open Forum Infectious Diseases"
DOI: 10.1093/ofid/ofy210.1231
Abstract: Abstract Background Plazomicin is a next-generation aminoglycoside (AG) with a structure that protects it from common AG resistance mechanisms in Enterobacteriaceae, and with in vitro activity against extended spectrum β-lactamase-producing and carbapenem-resistant Enterobacteriaceae. The purpose… read more here.
Keywords: healthy human; plazomicin healthy; mass; 14c plazomicin ... See more keywords
In Vivo Efficacy of Plazomicin Alone or in Combination with Meropenem or Tigecycline against Enterobacteriaceae Isolates Exhibiting Various Resistance Mechanisms in an Immunocompetent Murine Septicemia Model
Sign Up to like & getrecommendations! Published in 2018 at "Antimicrobial Agents and Chemotherapy"
DOI: 10.1128/aac.01074-18
Abstract: Plazomicin is a novel aminoglycoside with potent in vitro activity against multidrug- and carbapenem-resistant Enterobacteriaceae. The objective of this study was to assess the efficacy of plazomicin exposure, alone and in combination with meropenem or… read more here.
Keywords: septicemia; tigecycline; meropenem tigecycline; immunocompetent murine ... See more keywords
Inhibition of Enzymatic Acetylation-Mediated Resistance to Plazomicin by Silver Ions
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DOI: 10.3390/ph16020236
Abstract: Plazomicin is a recent U.S. Food and Drug Administration (FDA)-approved semisynthetic aminoglycoside. Its structure consists of a sisomicin scaffold modified by adding a 2(S)-hydroxy aminobutyryl group at the N1 position and a hydroxyethyl substituent at… read more here.
Keywords: acetylation; mediated resistance; silver; plazomicin ... See more keywords