A High-Throughput Assay to Identify Allosteric Inhibitors of the PLC-γ Isozymes Operating at Membranes.
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DOI: 10.1021/acs.biochem.0c00511
Abstract: The two phospholipase C-γ (PLC-γ) isozymes are major signaling hubs and emerging therapeutic targets for various diseases, yet there are no selective inhibitors for these enzymes. We have developed a high-throughput, liposome-based assay that features… read more here.
Keywords: assay identify; plc isozymes; allosteric inhibitors; throughput assay ... See more keywords