TREM2/PLCĪ³2 signalling in immune cells: function, structural insight, and potential therapeutic modulation
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DOI: 10.1186/s13024-021-00436-5
Abstract: The central role of the resident innate immune cells of the brain (microglia) in neurodegeneration has become clear over the past few years largely through genome-wide association studies (GWAS), and has rapidly become an active… read more here.
Keywords: trem2 plc; signalling immune; cells function; plc signalling ... See more keywords
Septins tune lipid kinase activity and PI(4,5)P2 turnover during G-proteinācoupled PLC signalling in vivo
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DOI: 10.26508/lsa.202101293
Abstract: In Drosophila photoreceptors, PI(4,5)P2 synthesis during PLC signalling is regulated by PIP5K and septins. Phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2] hydrolysis by phospholipase C (PLC) is a conserved mechanism of signalling. Given the low abundance of PI(4,5)P2, its… read more here.
Keywords: vivo; coupled plc; activity; mechanism ... See more keywords